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首页> 外文期刊>Journal of Medical Sciences >Severe Acne Vulgaris is Associated with Helicobacter pylori Infection: First Report in the Literature
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Severe Acne Vulgaris is Associated with Helicobacter pylori Infection: First Report in the Literature

机译：寻常痤疮与幽门螺杆菌感染有关：文献中的第一个报告

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Both Acne vulgaris and infection with Helicobacter pylori (HP) are very prevalent all over the world. The objective of this study was to examine possible association between HP infection and various severities of Acne vulgaris. In this case-control study, 100 adolescents and young adults were recruited from two educational dermatological centers in Tabriz over a one-year period (2012-2013), including 25 normal subjects (controls) and 75 patients with Acne vulgaris (mild = 25, moderate = 25, severe = 25). Infection with HP was investigated using 13C-urea Breath Test (UBT). Serum level of immunoglobulin G (IgG) against HP was also measured in all the participants. All the groups were matched for their participants? age and sex. The rate of HP infection was 56% in the control group, 60% in the cases with mild Acne vulgaris, 72% in the cases with moderate Acne vulgaris and 88% in the cases with severe Acne vulgaris. In terms of the rate of HP infection, there was no significant difference between the controls and the cases with mild Acne vulgaris (p = 0.77), nor between the controls and the patients with moderate Acne vulgaris (p = 0.24). The rate of HP infection, however, was significantly higher in the cases with severe Acne vulgaris comparing with the controls (p = 0.01). Mean serum level of IgG was also significantly higher in the same group (1.87±1.62 U vs. 2.98±1.29 U, p = 0.05). Based on the findings of the present study, a significant association was present between severe Acne vulgaris and HP infection. Further studies with larger sample sizes are recommended.
机译：寻常痤疮和幽门螺杆菌（HP）感染在世界各地非常普遍。这项研究的目的是检查HP感染和寻常痤疮的各种严重程度之间可能的关联。在这项病例对照研究中，在一年（2012年至2013年）期间，从大不里士的两个教育皮肤病学中心招募了100名青少年，其中包括25名正常受试者（对照组）和75名寻常痤疮患者（轻度= 25 ，中度= 25，重度= 25）。使用 13 C-尿素呼气试验（UBT）研究了HP感染。还测量了所有参与者的针对HP的血清免疫球蛋白G（IgG）水平。所有组都为他们的参与者配对了吗？年龄和性别。对照组中HP感染率是56％，轻度寻常型痤疮患者为60％，中度寻常型痤疮患者为72％，重度寻常型痤疮患者为88％。就HP感染率而言，对照组与轻度寻常型痤疮病例之间无显着差异（p = 0.77），而对照组与中度寻常型痤疮患者之间无显着差异（p = 0.24）。然而，与对照组相比，重症痤疮患者的HP感染率明显更高（p = 0.01）。同一组中的平均IgG血清水平也显着较高（1.87±1.62 U对2.98±1.29 U，p = 0.05）。根据本研究的发现，严重的寻常痤疮与HP感染之间存在显着关联。建议进行更大样本量的进一步研究。

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