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首页> 外文期刊>Journal of Medical Sciences >Demodex folliculorum and Skin Disease: A Case-Control Study
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Demodex folliculorum and Skin Disease: A Case-Control Study

机译：蠕形螨和皮肤疾病：病例对照研究

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Demodex mites are commensals of the pilosebaceous unit in human. This study aimed to investigate possible association of Demodex folliculorum with Basal Cell Carcinoma (BCC), Squamous Cell Carcinoma (SCC), melanoma, Discoid Lupus Erythematosus (DLE) and rosacea. In this case-control study, standardized skin surface biopsy samples were obtained from the cheeks of healthy individuals (n = 28); patients with BCC (n = 18), SCC (n = 13) and melanoma (n = 11) and patients with DLE (n = 28) and inflammatory rosacea (n = 34). Mite density (cm-2) and the rate of infestation (density ≥5) were compared. The rate of mite infestation (%) was comparable between the controls (21.4) and the patients with BCC (22.2, p = 0.95), SCC (18.8, p = 0.83), melanoma (9.1, p = 0.37) and DLE (17.9, p = 0.74). Infestation was significantly more frequent in the rosacea group (47.1, p = 0.04) than in the controls. While, the mean mite density (cm-2) was comparable between the control (4.07±2.06) and the groups with BCC (5.01±2.08, p = 0.68), SCC (3.17±1.29, p = 0.49) and DLE (3.26±1.04, p = 0.91); it was significantly higher in the group of rosacea (8.56±3.29, p = 0.03) and lower in the group of melanoma (1.45±0.58, p = 0.04) in comparison with the normal group. In conclusion, although Demodex folliculorum does not seem to play a role in the pathogenesis of BCC, SCC and DLE, it is apparently associated with rosacea and melanoma.
机译：蠕形螨是人类毛囊皮脂单位的代名词。这项研究旨在调查蠕形螨与基底细胞癌（BCC），鳞状细胞癌（SCC），黑素瘤，盘状红斑狼疮（DLE）和酒渣鼻的可能联系。在这个病例对照研究中，从健康个体的脸颊上获得了标准化的皮肤表面活检样本（n = 28）。 BCC（n = 18），SCC（n = 13）和黑色素瘤（n = 11）患者以及DLE（n = 28）和炎性酒渣鼻（n = 34）患者。比较螨的密度（cm -2 ）和侵染率（密度≥5）。在对照组（21.4）和BCC（22.2，p = 0.95），SCC（18.8，p = 0.83），黑素瘤（9.1，p = 0.37）和DLE（17.9）的患者之间，螨虫侵袭率（％）相当。 ，p = 0.74）。与对照组相比，酒渣鼻组的侵扰发生率明显更高（47.1，p = 0.04）。而对照组的平均螨虫密度（cm -2 ）与对照组（4.01±2.06）和BCC组（5.01±2.08，p = 0.68），SCC（3.17±1.29，p = 0.49）和DLE（3.26±1.04，p = 0.91）;与正常组相比，酒渣鼻组明显较高（8.56±3.29，p = 0.03），黑素瘤组较低（1.45±0.58，p = 0.04）。总而言之，尽管蠕形蠕形螨似乎在BCC，SCC和DLE的发病机理中不起作用，但显然与酒渣鼻和黑色素瘤有关。

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