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Effects of Valproat and Clonazepam on Kidney Tissue of Female Rats

机译：丙戊酸和氯硝西am对雌性大鼠肾脏组织的影响

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The aim of this study was to investigate the histotoxic effects of sodium valproat and clonazepam on kidney tissue. It was used which weights 270 to 300 g and 7 to 8 months Sprague Dawley female rats. Five groups were prepared for the experimentations and 0.5 mL serum physiologic was given in I Group (control), in the other groups were given 150 mg kg-1 sodium valproat in II Group and 300 mg kg-1 sodium valproat in III Group, 0.25 mg kg-1 clonazepam in IV Group and 0.50 mg kg-1 clonazepam in the V Group, respectively, as intra peritoneal at the same time for each day in the 7 days. In the kidney tissue sections, it was observed the normal structural properties in I and II Groups, distal tubular dilatations in III and IV Groups and the normal histological structures in V Group. In the II Group which was given 150 mg kg-1 of sodium valproat, the structures in kidney were found as the similar to that of the control. The kidney cortex of III Group which was given 300 mg kg-1 sodium valproat has been observed the dilatations in the distal tubules and the some infiltrations have been around of the glomerulus`s. The epilepsies are a range of multifaceted disorders that can be affected many aspects of a person`s life. No single outcome measure can reflect their complex nature and impact in the individual patient. The aim of drug treatment is the prevention of symptoms with no or tolerable side-effects. While this is possible for the majority of patients, there remains a significant proportion in whom ongoing symptoms and increasing drug burden exact a heavy toll.
机译：这项研究的目的是研究丙戊酸钠和氯硝西am对肾脏组织的组织毒性作用。使用重量为270至300克，体重为7至8个月的Sprague Dawley雌性大鼠。实验分为5组，I组（对照组）给予0.5 mL血清生理盐水，II组其他组分别给予150 mg kg -1 丙戊酸钠和300 mg kg -1 丙戊酸钠，IV组0.25 mg kg -1 氯硝西am和V组分别为0.50 mg kg -1 氯硝西am在7天内的每天同一时间腹膜内注射。在肾组织切片中，观察到I和II组的正常结构特性，III和IV组的远端肾小管扩张以及V组的正常组织学结构。在II组中，给予150 mg kg -1 丙戊酸钠，发现肾脏中的结构与对照组相似。观察到III组肾皮质给予丙戊酸钠300 mg kg -1 的剂量，并观察到远端肾小管扩张，部分肾小球周围有浸润。癫痫病是一系列多方面的疾病，可以影响一个人生活的许多方面。没有单一的结果指标可以反映出其复杂的性质和对个别患者的影响。药物治疗的目的是预防无副作用或可忍受的副作用。虽然这对于大多数患者而言都是可能的，但仍有相当一部分患者持续出现的症状和不断增加的药物负担造成沉重的伤亡。

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