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首页> 外文期刊>Journal of Medical Sciences >Effect of Antiretroviral Therapy on Lipid Metabolism in HIV/AIDS Subjects in Cameroon
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Effect of Antiretroviral Therapy on Lipid Metabolism in HIV/AIDS Subjects in Cameroon

机译：抗逆转录病毒疗法对喀麦隆艾滋病毒/艾滋病患者脂质代谢的影响

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This study sets out to investigate the effect of anti-retroviral therapy on lipid metabolism in HIV/AIDS patients in Cameroon. A descriptive and prospective study was carried out on 16 HIV/AIDS individuals with CD4 counts of less than 200 cells mm-3 and on antiretroviral drugs. The various drug regimens included Nevirapine-Lamivudine-Stavudine and Efavirenz-Lamivudine-Stavudine/or Zidovudine. No patients were on protease inhibitors. All patients were monitored at baseline and then monthly thereafter for 3 months. A complete clinical examination and blood samples were respectively collected for total cholesterol, LDL-cholesterol, HDL- cholesterol, triglycerides, Apolipoproteins A1 (ApoA1) and B100 (ApoB100). Total cholesterol and LDL cholesterol levels increased significantly (p1 levels was noted to rise significantly (p100 and the total cholesterol/ HDL cholesterol ratio remained unaltered. The increase of total and LDL-cholesterols may serve as indicators for the risk of cardiovascular disease in HIV/AIDS patients on antiretroviral drugs. The biosynthesis of HDL lipoprotein could also be associated with antiretroviral therapy.
机译：这项研究着手研究抗逆转录病毒疗法对喀麦隆HIV / AIDS患者脂质代谢的影响。对16名CD 4 计数小于200个细胞mm -3 的HIV / AIDS患者和抗逆转录病毒药物进行了描述性和前瞻性研究。各种药物方案包括奈韦拉平-拉米夫定-司他夫定和依非韦伦-拉米夫定-司他夫定/或齐多夫定。没有患者使用蛋白酶抑制剂。在基线时对所有患者进行监测，然后每月监测3个月。进行完整的临床检查并采集血液样本中的总胆固醇，低密度脂蛋白胆固醇，高密度脂蛋白胆固醇，甘油三酸酯，载脂蛋白A 1 （ApoA 1 ）和B 100 （ApoB 100 ）。总胆固醇和低密度脂蛋白胆固醇水平显着增加（p1 水平显着上升（p100 ，总胆固醇/高密度脂蛋白胆固醇比率保持不变）。总胆固醇和低密度脂蛋白胆固醇的增加可能是指示HIV / AIDS患者使用抗逆转录病毒药物治疗心血管疾病的风险; HDL脂蛋白的生物合成也可能与抗逆转录病毒治疗有关。

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