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首页> 外文期刊>Journal of Medical Sciences >Antioxidant Effect of Arabic Gum Against Paraquat-induced Lung Oxidative Stress in Mice
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Antioxidant Effect of Arabic Gum Against Paraquat-induced Lung Oxidative Stress in Mice

机译：阿拉伯胶对百草枯引起的小鼠肺氧化应激的抗氧化作用

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The effect of Arabic Gum (AG) against toxicity of paraquat (PQ), an oxidative stress inducing substance, in mice was investigated. A single dose of PQ (30 mg kg-1, i.p.) induced lung toxicity, manifested biochemically by significant decrease of the activity of alkaline phosphatase enzyme (ALP) in lung tissue. Lung toxicity was further evidenced by significant decrease of total sulfhydryl (-SH) content and significant increase in lipid peroxidation measured as malondialdehyde (MDA) in lung tissues. Pretreatment of mice with AG (25 g kg-1 p.o.) in drinking water, starting 5 days before PQ injection and continuing during the experimental period ameliorated the lung toxicity induced by PQ. This was evidenced by prevention of the significant decrease in ALP activity, the total sulfhydryl content and the significant increase in MDA in lung tissue homogenates compared to the PQ treated group. Moreover, pretreatment of mice with AG leads to an increase of the LD50 value of PQ. These results indicate that AG is an efficient cytoprotective agent against PQ-induced lung toxicity.
机译：研究了阿拉伯胶（AG）对百草枯（PQ）（一种氧化应激诱导物质）的毒性在小鼠中的作用。单剂量PQ（30 mg kg -1 ，i.p.）诱发肺毒性，其生化表现为肺组织中碱性磷酸酶（ALP）活性明显降低。肺毒性进一步通过总巯基（-SH）含量的显着降低和肺组织中丙二醛（MDA）测得的脂质过氧化显着增加进一步证明。 PQ注射前5天开始，在饮用水中对AG（25 g kg -1 p.o. p.o.）小鼠进行预处理，并在实验期间持续改善了PQ诱导的肺毒性。与PQ处理组相比，通过预防肺组织匀浆中ALP活性，总巯基含量和MDA的显着增加，可以证明这一点。此外，用AG预处理小鼠会导致PQ的LD 50 值增加。这些结果表明，AG是对抗PQ诱导的肺毒性的有效细胞保护剂。

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