• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Medical Sciences >Latency Prolongation of P300 Event Related Potentials in Patients with and Without Asymptomatic Cerebral Infarction
【24h】

Latency Prolongation of P300 Event Related Potentials in Patients with and Without Asymptomatic Cerebral Infarction

机译：有无无症状性脑梗死的患者P300事件相关电位的潜伏期延长

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In this study, we evaluate the changes on the Events-Related Potentials (ERPs) of P300 in patients with asymptomatic cerebral infarction which was detected by Magnetic Resonance Imaging (MRI). We examined 37 patients who visited University Hospital with complaint of headache or dizziness which had no episodes of stroke nor any neurological defect including obvious dementia between March 1988 to March 2000. MRI were performed and we found 23 cases of patients showed multiplelacunar infarction and 14 patients (8 male and 6 female) (with average age of 70) showed marked leuko-araiosis or periventricular high intensity with or without lacunar infarction in T2-weight image. We compared these two group with 13 healthy age-match (7 male and 6 female with average age of 68) as control group. ERPs was recorded with a band-pass filter of 0.01-120 c s-1. ERPs were derived from the Fz, Cz and Pz referenced to linked earlobe electrode and mini-mental test were performed in all subject. P300 ERPs were recorded by standard oddball paradigm with the subject seated in a reclined easy chair. In auditory paradigms, during the subject?s eyes were closed, 2,000 Hz tone were used as target and 1,000 Hz tone as none target through headphone. The target tone were presented in a random sequence at the rate of 20%. Then the subjects were instruct to count the number of target tone. Statistical analysis was performed using one factor ANOVA to determine inter-group differences. P300 latency in patients MRI showed multiple lacunar infarction (378.8±33.6 ms) and in patients MRI showed marked leuko-araiosis infarction (388.3±3.6 ms), were significantly prolonged as compare to normal healthy person (338.6±13.5 ms). However, the amplitude of P300 was remain unchanged. The scores obtained from Mini Mental State Test (MMST) were showed no significantly different between the normal elderly and patient with multiple lacunar infarction and in leuko-araiosis infarction patients Comparison the latency and amplitude of N100, P200 and N200 were also no significantly differences. The present finding, we found the P300 latency was significantly prolong in multiple lacunar infarction patients and in leuko-araiosis infarction patients. But there were no significant changes in the amplitude of P300. Thus, we can concluded that cognitive function was impaired with asymptomatic cerebral infarction.
机译：在这项研究中，我们评估了通过磁共振成像（MRI）检测到的无症状性脑梗死患者P300事件相关电位（ERP）的变化。我们检查了1988年3月至2000年3月间就诊的头痛或头晕，无中风发作，无神经系统疾病（包括明显的痴呆）在内的37例就诊的大学医院。进行了MRI检查，发现23例患有多发性腔隙性脑梗死的患者和14例患者T 2 体重图像中（男8例，女6例）（平均年龄70岁）表现出明显的白细胞疏松或脑室高强度，有或无腔隙性梗塞。我们将这两组人与13位健康的年龄匹配者（男性7位，女性6位，平均年龄68岁）进行了比较。用0.01-120 c s -1 的带通滤波器记录ERPs。 ERPs是从Fz，Cz和Pz派生而来的，该Fz，Cz和Pz参考了链接的耳垂电极，并在所有受试者中进行了小型心理测试。通过标准的奇数球范例记录P300 ERP，受试者坐在倾斜的安乐椅上。在听觉范例中，在受试者闭眼期间，通过耳机将2,000 Hz音作为目标，将1,000 Hz音作为无目标。目标音调以20％的随机顺序出现。然后指示对象计数目标音调的数量。使用一因素方差分析进行统计分析以确定组间差异。 MRI患者的P300潜伏期显示为多发性腔隙性梗塞（378.8±33.6 ms），而MRI患者的P300潜伏期显示为显着的白质疏松性梗塞（388.3±3.6 ms），与正常健康人相比明显延长（338.6±13.5 ms）。但是，P300的幅度保持不变。从迷你精神状态测验（MMST）获得的分数显示，正常老年人与多腔隙性脑梗死患者和白细胞疏松性脑梗死患者之间无显着差异。N100，P200和N200的潜伏期和振幅也无显着差异。目前的发现，我们发现多发腔隙性脑梗死患者和白细胞疏松性梗死患者的P300潜伏期显着延长。但是P300的幅度没有明显变化。因此，我们可以得出结论，无症状性脑梗塞损害了认知功能。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号