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首页> 外文期刊>Journal of Medical Sciences >New Vistas in the Therapeutic Uses of Stem Cells
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New Vistas in the Therapeutic Uses of Stem Cells

机译：干细胞治疗用途的新视野

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Stem cell technology has emerged in the face of extraordinary advances for prevention, diagnosis and treatment of human diseases such as heart disease, diabetes, cancer and diseases of the nervous system, such as Parkinson’s disease and Alzheimer’s Disease (AD). It offers great promise for tissue regeneration, cell replacement and gene therapy, but clinical applications remain limited. Despite considerable ethical and practical barriers to their acceptance in the society, their potential in medicine is tantalising. There is a balance between the search for ways to regenerate bodies ravaged by age and disease on the one hand, with the need to ground these ideas in scientific fact and medical caution on the other. Stem cells are certainly exciting both as models of developmental biology and potential in human disease. Brain can be turned into blood, blood can be turned into brain, muscle, myocardium or liver and in some hands, bone marrow and neural stem cells can be turned into almost any type of cell. Such remarkable properties render it now feasible to contemplate isolating living healthy stem cells from the body, expanding them under cell culture conditions, combining them with biocompatible carrier molecules, directing their proliferation with growth factors and then transplanting them or their progeny into patients for clinical gain. In this way stem cells may, in future, be used to alleviate degenerative disorders, replace diseased or failing tissues with engineered substitutes and correct genetic disease. These living tissue substitutes may indeed overcome the drawbacks of classic transplantation and the limitations of standard treatments for degenerative disease, but their origins and potential are increasingly challenged by developments in science and medicine, politics and ethics.
机译：在预防，诊断和治疗人类疾病（如心脏病，糖尿病，癌症和神经系统疾病，如帕金森氏病和阿尔茨海默氏病（AD））方面，干细胞技术应运而生。它为组织再生，细胞置换和基因治疗提供了广阔前景，但临床应用仍然有限。尽管在社会上接受它们有相当多的道德和实践障碍，但它们在医学上的潜力却令人着迷。在一方面寻求再生受年龄和疾病破坏的尸体的方法，另一方面需要在科学事实和医学注意方面扎根这些思想之间存在平衡。作为发育生物学的模型和人类疾病的潜能，干细胞无疑是令人兴奋的。大脑可以变成血液，血液可以变成大脑，肌肉，心肌或肝脏，在某些手中，骨髓和神经干细胞可以变成几乎任何类型的细胞。如此卓越的性能使得现在可以设想从体内分离出健康的健康干细胞，在细胞培养条件下对其进行扩增，将其与生物相容性载体分子结合，将其与生长因子一起定向增殖，然后将其或其后代移植到患者体内以获取临床收益。 。通过这种方式，干细胞将来可用于缓解变性疾病，用工程替代品替代患病或衰竭的组织并纠正遗传疾病。这些活体组织替代品的确可以克服经典移植的弊端和退行性疾病的标准疗法的局限性，但它们的起源和潜力正日益受到科学，医学，政治和伦理学发展的挑战。

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