Effect of Guiera senegalensis Leaf Extract on Some Echis carinatus Venom Enzymes

A.B. Sallau; G.C. Njoku; A.R. Olabisi; A.U. Wurochekke; A.A. Abdulkadir; Shehu Isah; M.S. Abubakar; S. Ibrahim

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Effect of Guiera senegalensis Leaf Extract on Some Echis carinatus Venom Enzymes

机译：塞内加尔虎尾草叶提取物对一些棘皮car蛇毒酶的影响

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Aqueous extract of Guiera senegalensis leaves was investigated for the inhibitory action on the activity of crude phospholipase and metalloprotease enzymes from Echis carinatus venom. Both enzymes were inhibited by the extract in a dose dependent fashion. Double reciprocal plots of the initial velocity data of the inhibition by the extract revealed a non-competitive pattern of inhibition for the metalloprotease and a competitive one for the phospholipase. Extrapolated Ki values were found to be 11.9 and 90 μg mL^-1 for the metalloprotease and phospholipase, respectively.

机译：研究了塞内加尔圭亚那叶子的水提取物对棘皮E蛇毒中粗磷脂酶和金属蛋白酶活性的抑制作用。提取物以剂量依赖性方式抑制两种酶。提取物抑制作用的初始速度数据的双倒数图显示了金属蛋白酶抑制作用的非竞争性模式和磷脂酶抑制作用的竞争性模式。金属蛋白酶和磷脂酶的外推Ki值分别为11.9和90μgmL ^{-1 。}

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《Journal of Medical Sciences》 |2005年第4期|共4页
作者
A.B. Sallau; G.C. Njoku; A.R. Olabisi; A.U. Wurochekke; A.A. Abdulkadir; Shehu Isah; M.S. Abubakar; S. Ibrahim;
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1. Effect of Guiera senegalensis Leaf Extract on Some Echis carinatus Venom Enzymes [J] . A.B. Sallau, G.C. Njoku, A.R. Olabisi, Journal of Medical Sciences . 2005,第4期

机译：塞内加尔虎尾草叶提取物对一些棘皮car蛇毒酶的影响
2. Local and systemic toxicity of Echis carinatus venom: neutralization by Cassia auriculata L. leaf methanol extract [J] . Urs A. N. Nanjaraj, Yariswamy M., Joshi Vikram, Journal of natural medicines . 2015,第1期

机译：棘皮E蛇毒的局部和全身毒性：决明子叶片甲醇提取物的中和作用
3. In vitro snake venom detoxifying action of the leaf extract of Guiera senegalensis. [J] . Abubakar MS, Sule MI, Pateh UU, Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs . 2000,第3期

机译：塞内加尔圭亚那叶提取物的体外蛇毒解毒作用。
4. DEEP PROTEOMICS OF SAW-SCALED VIPER (ECHIS CARINATUS SOCHUREKI) VENOM BY INTEGRATED TOP-DOWN AND BOTTOM-UP MASS SPECTROMETRIC APPROACHES [C] . Parviz Ghezellou, Vannuruswamy Garikapati, Seyed Mahdi Kazemi, International Mass Spectrometry Conference . 2018

机译：通过集成的自上而下和自下而上的质谱方法，锯鳞蛇（Echis Carinatus Sochureki）的深蛋白质组学毒液
5. The Effect of Artichoke Leaf Extract (Cyanara scolymus L.) on the Pharmacokinetic Profile of Rosuvastatin in Rats Plasma and Their Lipid Lowering Effect by Using HPLC and a Fully Automated Chemistry Analyzer (Snibe? Bioassay 240 Plus) [D] . Al Masalmeh, Ahmad Moussa. 2021

机译：朝鲜蓟叶萃取物（Cyanara scolymus L.）对大鼠血浆中罗苏伐他汀药代动力学谱的影响及其使用HPLC和全自动化学分析仪（SNIBE？Bioassay 240加）
6. Asp-49 is not an absolute prerequisite for the enzymic activity of low-M(r) phospholipases A2: purification characterization and computer modelling of an enzymically active Ser-49 phospholipase A2 ecarpholin S from the venom of Echis carinatus sochureki (saw-scaled viper). [O] . J Polgár, E M Magnenat, M C Peitsch, 1996

机译：Asp-49不是低M（r）磷脂酶A2的酶活性的绝对先决条件：纯化鉴定和计算机建模的酶活性Ser-49磷脂酶A2赤藓素S的化学成分来自蛇ven（Echis carinatus sochureki）的毒液（锯）规模的毒蛇）。
7. Asp-49 is not an absolute prerequisite for the enzymic activity of low-M(r) phospholipases A2: purification, characterization and computer modelling of an enzymically active Ser-49 phospholipase A2, ecarpholin S, from the venom of Echis carinatus sochureki (saw-scaled viper). [O] . Polgár, J, Magnenat, E M, Peitsch, M C, 1996

机译：Asp-49不是低M（r）磷脂酶A2的酶活性的绝对先决条件：纯化，鉴定和计算机建模的酶活性Ser-49磷脂酶A2赤藓素S的化学成分来自蛇ven（Echis carinatus sochureki）的毒液（锯）规模的毒蛇）。

Effect of Guiera senegalensis Leaf Extract on Some Echis carinatus Venom Enzymes

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