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首页> 外文期刊>Journal of Medical Sciences >Attenuation of Restraint-induced Anorexia and Anxiogenic Behavior by Serotonin-1A Agonists in Rats
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Attenuation of Restraint-induced Anorexia and Anxiogenic Behavior by Serotonin-1A Agonists in Rats

机译：血清素1A激动剂对大鼠的约束性厌食和焦虑行为的减弱

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The present study was designed to investigate the effects of buspirone (a partial 5-HT 1A receptor agonist) and 8-hydroxy-2-(di-n-propylamino) tetraline (8-OH-DPAT, a full 5-HT 1A receptor agonist) on restraint-induced behavioral deficits. Exposure to a single episode of 2 h restraint stress decreased food intake , growth rate and elicited anxiogenic like behavior in rats. Prior administration of buspirone and 8-OH-DPAT attenuated stress-induced behavioral deficits of food intake and exploratory activity in a light-dark box. Novelty-induced anxiety in unrestrained animals was also diminished by prior administration of 8-OH-DPAT but not buspirone. The effects on the attenuation of restraint-induced anorexia were greater in 8-OH-DPAT than buspirone injected animals. The results are discussed in the context of a role of somatodendritic as well as postsynaptic 5-HT 1A receptors in the attenuation of restraint-induced behavioral deficits.
机译：本研究旨在研究丁螺环酮（部分5-HT 1A受体激动剂）和8-羟基-2-（二-正丙基氨基）四氢萘（8-OH-DPAT，一种完整的5-HT 1A受体）的作用激动剂）抑制约束引起的行为缺陷。暴露于2小时的单次约束压力下会减少大鼠的食物摄入量，生长速率并引发类似焦虑的行为。预先使用丁螺环酮和8-OH-DPAT可以减轻应激引起的食物摄取行为和行为的不足，并在浅色暗盒中进行。通过事先服用8-OH-DPAT而不是丁螺环酮，也可以减少不受限制的动物的新颖性焦虑。在8-OH-DPAT中，对约束诱导的厌食症的缓解作用要比丁螺环酮注射的动物大。在树突状以及突触后5-HT 1A受体在抑制约束性行为缺陷中的作用中讨论了结果。

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