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首页> 外文期刊>Journal of Medical Case Reports >Non-vertebral Veillonella species septicemia and osteomyelitis in a patient with diabetes: a case report and review of the literature
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Non-vertebral Veillonella species septicemia and osteomyelitis in a patient with diabetes: a case report and review of the literature

机译：糖尿病患者非脊椎韦荣氏菌属败血症和骨髓炎：一例病例并文献复习

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Introduction Veillonella is a nonfermentative, strictly anaerobic, Gram-negative coccus that forms part of the human gastrointestinal tract, mouth and vaginal flora. Like other anaerobic infection, Veillonella species usually are involved in polymicrobial processes, which make it difficult to determine their pathogenic role. Isolation of a clinically significant Veillonella species is rare and V. parvula is the most common one reported to cause infection in humans. The most frequently reported infection caused by V. parvula is osteomyelitis, almost always in association with bacteremia. Case presentation Here, we describe a rare case of nonvertebral osteomyelitis and septicemia caused by Veillonella species in a 49-year-old Saudi man with diabetes. Initial treatment with ciprofloxacin was associated with treatment failure and poor response. Identification of the organism was essential for the selection of appropriate treatment. There have been only seven previous reports of Veillonella vertebral osteomyelitis and one report of V. parvula foot osteomyelitis with sepsis in the literature. This is the second case of Veillonella nonvertebral osteomyelitis associated with septicemia reported to date. Conclusions Veillonella species should be considered a true pathogen in diabetic patients with osteomyelitis and those with underlying immune suppression, particularly if the organism is isolated from blood. The isolation of those obligate anaerobes from blood may signal the presence of severe underlying disease and the probable need for timely surgical intervention.
机译：简介Veillonella是一种非发酵性的，严格厌氧的，革兰氏阴性的球菌，构成人胃肠道，口腔和阴道菌群的一部分。像其他厌氧菌感染一样，Veillonella菌种通常也参与了微生物的繁殖过程，因此很难确定其致病作用。分离出临床上具有重要意义的Veillonella菌种非常罕见，小小弧菌是据报道可引起人类感染的最常见的一种。由小肠弯曲杆菌引起的最常报告的感染是骨髓炎，几乎总是与菌血症有关。病例介绍在这里，我们描述了49位沙特阿拉伯糖尿病患者中由Veillonella菌种引起的非椎骨骨髓炎和败血病的罕见病例。环丙沙星的初始治疗与治疗失败和不良反应有关。鉴定生物体对于选择适当的治疗至关重要。文献中仅有7篇报道了Veillonella椎骨骨髓炎，而另一篇报道有小肠败血性小腿足部骨髓炎并伴有败血症。这是迄今为止报道的第二例与败血病有关的韦永氏杆菌非椎骨骨髓炎。结论对于患有骨髓炎和潜在免疫抑制的糖尿病患者，尤其是从血液中分离出这种微生物时，应将维永氏菌属视为真正的病原体。从血液中分离出那些专性厌氧菌可能表明存在严重的潜在疾病，并且可能需要及时进行手术干预。

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