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首页> 外文期刊>Journal of Microbiology and Infectious Diseases >Profile of Person Affected by Leprosy with Clinical Relapse among in High Endemic State of India
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Profile of Person Affected by Leprosy with Clinical Relapse among in High Endemic State of India

机译：印度高流行地区麻风病患者的临床复发情况

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Objective: Relapse is not an unusual phenomenon in leprosy, there are many predisposing factors which may lead to occurrence of relapse; some of these include the presence of persistent bacilli, drug monotherapy, inadequate or irregular therapy. Patients usually presents with presence of multiple skin lesions and/or thickened nerves, reason for early relapse is probably bacillary persistence due to inadequate treatment and for late relapse due to or re-infection. The objectives of this study are to assess various clinico-epidemiological factors associated with the occurrence of relapses in leprosy patients. Methods: A hospital record based retrospective follow-up study has been performed and 117 relapse cases of leprosy were included. Leprosy relapse cases presented in the study hospital were interviewed using a predesigned and pretested preformed. Each patient was subjected to clinical, bacteriological and disability assessments for diagnosis of relapse and followed until the completion of multi drug therapy. Results: During a study period, relapse was seen more in male as compared to female. The duration between cessation of the treatment and re-appearance of new lesions varied from 1 to 33 years. Disability proportion was high among MB patients. Conclusion: Relapse in leprosy should be thoroughly examined and looked for drug resistance.
机译：目的：复发不是麻风病中的异常现象，有很多诱发因素可能导致复发。其中一些包括持续存在的细菌，药物单一疗法，治疗不足或不规律。患者通常表现为多处皮肤病变和/或神经增厚，早期复发的原因可能是由于治疗不充分而导致的细菌持续性以及由于或再次感染导致的晚期复发。这项研究的目的是评估与麻风病人复发有关的各种临床流行病学因素。方法：已经进行了一项基于医院记录的回顾性随访研究，其中包括117例麻风病复发病例。使用预先设计和预先测试的预制棒对在研究医院出现的麻风复发病例进行了采访。对每位患者进行临床，细菌学和残疾评估以诊断复发，然后随访直至完成多药治疗。结果：在研究期间，男性复发率高于女性。停止治疗与重新出现新病变之间的持续时间为1至33年。 MB患者中残疾比例很高。结论：应彻底检查麻风病复发，并寻找耐药性。

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