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首页> 外文期刊>Journal of Microbiology, Biotechnology and Food Sciences >ANTIOXIDATIVE PROPERTIES OF ETHYL ACETATE FRACTION OF UNRIPE PULP OF CARICA PAPAYA IN MICE
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ANTIOXIDATIVE PROPERTIES OF ETHYL ACETATE FRACTION OF UNRIPE PULP OF CARICA PAPAYA IN MICE

机译：番木瓜原浆的乙酸乙酯乙酸乙酯部分的抗氧化性能

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Unripe Carica papaya fruits were extracted with methanol in Soxhlet apparatus and later with a liquid-liquid extraction with the aim of identifying and quantifying secondary metabolite fraction of this plant. Quercetin and β-sitosterol have been isolated from the fruit and the quantities detected were 120.2±0.16 mg/g (dry fruit) and 279.1±0.09mg/g respectively. In addition, the extracts were evaluated in vivo for their effects on activities of some antioxidant enzymes which includes Glutathione peroxidase (GPx), Glutathione reductase (GR), Glutathione transferase (GST), Catalase (CAT) and metabolizing enzyme Glucose-6-phosphate dehydrogenase (G6PDH) in mice treated orally with a daily dose of extracts (100mg/kg) for 7 days. Results showed that ethyl acetate fraction caused significant increase(p<0.05) in the activities of GR, GPx, GST, and G6PDH. Significant decrease (p<0.05) in GPx activity was observed in kidney following administration of ethyl acetate fraction. It is likely that quercetin and β-sitosterol may be responsible for the antioxidant potential demonstrated by the ethyl acetate fraction from unripe fruit.
机译：未成熟的番木瓜果实用索氏提取器用甲醇萃取，然后用液-液萃取，目的是鉴定和定量该植物的次生代谢产物。从水果中分离出槲皮素和β-谷固醇，检出量分别为（干果）120.2±0.16 mg / g和279.1±0.09mg / g。此外，在体内评估了提取物对某些抗氧化酶活性的影响，这些抗氧化酶包括谷胱甘肽过氧化物酶（GPx），谷胱甘肽还原酶（GR），谷胱甘肽转移酶（GST），过氧化氢酶（CAT）和代谢酶葡萄糖-6-磷酸。每天用提取物（100mg / kg）口服治疗7天的小鼠体内脱氢酶（G6PDH）。结果表明，乙酸乙酯组分导致GR，GPx，GST和G6PDH的活性显着增加（p <0.05）。给予乙酸乙酯级分后，肾脏中GPx活性显着下降（p <0.05）。槲皮素和β-谷固醇可能是未成熟果实中乙酸乙酯成分所证明的抗氧化剂潜力的原因。

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