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首页> 外文期刊>Journal of Microbiology, Biotechnology and Food Sciences >BISPHENOL A AND ITS POTENTIAL TOXIC EFFECTS ON LIVING ORGANISMS
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BISPHENOL A AND ITS POTENTIAL TOXIC EFFECTS ON LIVING ORGANISMS

机译：双酚A及其对生物体的潜在毒性作用

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摘要

Bisphenol A (BPA), 2, 2,-bis (4-hydroxyphenyl) propane, CAS No. 80-05-7, is an industrial chemical that is made by combining acetone and phenol. Food is acknowledged to be a main source of exposure to BPA as a consequence of BPA migration from food containers. Several studies have reported BPA migrations from can surface coatings or plastics into foods and food-simulating liquids at high temperatures, and with repeated use of plastic products. Evaluation of BPA confirmed a no-observable adverse effect level (NOAEL) of 5 mg/kg/body weight/day and established a maximum total daily intake (TDI) of 0.05 mg/kg body weight. A metabolism of BPA is characterized mainly by phase II conjugation reactions in the gastrointestinal tract and in the liver. The presence of BPA in the environment can cause serious health problems (endocrine disruptions, neurotoxic, genotoxic and other problems). However, there are controversial opinions about BPA. Based on current knowledge of literature the need for further experimental studies in addressing health of human and animal populations living in different ecosystems may be still useful.
机译：双酚A（BPA），2，2，-双（4-羟苯基）丙烷（CAS No. 80-05-7）是一种工业化学产品，由丙酮和苯酚混合制成。由于BPA从食品容器中迁移出来，因此食品被认为是BPA暴露的主要来源。几项研究报告了BPA在高温下从罐表面涂料或塑料迁移到食品和食品模拟液体中，并反复使用塑料产品。对BPA的评估证实了5 mg / kg /体重/天的不可观察到的不良反应水平（NOAEL），并确定了0.05 mg / kg体重的最大每日总摄入量（TDI）。 BPA代谢的主要特征是胃肠道和肝脏中的II期结合反应。环境中双酚A的存在会引起严重的健康问题（内分泌紊乱，神经毒性，遗传毒性和其他问题）。但是，有关BPA的观点存在争议。根据目前的文献知识，需要进一步的实验研究来解决生活在不同生态系统中的人类和动物种群的健康问题可能仍然有用。

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