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首页> 外文期刊>Journal of Ayub Medical College >EXPRESSION OF P53 IN OVARIAN EPITHELIAL TUMOURS AND ITS CORRELATION WITH HISTOPATHOLOGICAL PARAMETERS
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EXPRESSION OF P53 IN OVARIAN EPITHELIAL TUMOURS AND ITS CORRELATION WITH HISTOPATHOLOGICAL PARAMETERS

机译：P53在卵巢上皮肿瘤中的表达及其与组织病理学参数的关系

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Background: Ovarian cancers are the leading cause of death among gynaecologic neoplasms. The most common form of ovarian tumours is surface epithelial tumours divided as benign, borderline and malignant. Of particular interest are borderline tumours, because the pathologist may rely on some what vague morphologic criteria. The aim of this study was to evaluate the correlation of tumour suppressor protein P53 with macroscopic and microscopic criteria of ovarian surface epithelial tumours and distinction of borderline from malignant tumours. Methods: We studied 109 ovarian neoplasms including 74 benign, 8 borderline and 27 malignant ovarian epithelial tumours during March 2006–March 2011 in Urmia University of Medical Sciences. Immuno-histochemical staining for P53 performed on paraffin blocks and quantified with 12- point weighted score proposed by W.Y chan. Results: Mean P53 weighted scores in benign, borderline and malignant tumours were 0.20±0.63, 0.76±0.89 and 3.79±4.20, respectively. There was significant difference between malignant and borderline tumours( p =0.002) and between malignant and benign ones ( p =0.000).None of 11 immuno-reactive benign and 4 borderline tumours showed P53 expression in 50% of tumour cells, but 11 out of 15 immuno-reactive malignant tumours (73.3%) expressed p53 in 50% of tumour cells. P53 score significantly increases with mitotic count ( p =0.000) and solidification of the tumour ( p =0.001). There was no significant correlation with size ( p =0.277), papillary structures ( p =0.062) and grade ( p =0.578). Conclusion: According to our results, P53 staining can be used as a helpful method in distinction of borderline from malignant ovarian epithelial tumours, especially in the manner that expression in 50% of cells favouring malignancy.
机译：背景：卵巢癌是妇科肿瘤中死亡的主要原因。卵巢肿瘤最常见的形式是表面上皮肿瘤，分为良性，边缘性和恶性。特别重要的是边缘肿瘤，因为病理学家可能依赖一些模糊的形态学标准。这项研究的目的是评估抑癌蛋白P53与卵巢表面上皮性肿瘤的宏观和微观标准之间的相关性以及恶性肿瘤的界限。方法：我们在2006年3月至2011年3月期间于Urmia医科大学研究了109例卵巢肿瘤，包括74例良性，8例交界性和27例恶性卵巢上皮肿瘤。对P53的免疫组织化学染色在石蜡块上进行，并由W.Y chan提出的12点加权评分进行量化。结果：良性，交界性和恶性肿瘤的P53加权平均得分分别为0.20±0.63、0.76±0.89和3.79±4.20。恶性和交界性肿瘤之间存在显着差异（p = 0.002），恶性和良性肿瘤之间存在显着差异（p = 0.000）。11种免疫反应性良性和4种交界性肿瘤中没有一个在> 50％的肿瘤细胞中显示P53表达，但是11种在超过50％的肿瘤细胞中，有15种免疫反应性恶性肿瘤（73.3％）表达了p53。 P53分数随有丝分裂计数（p = 0.000）和肿瘤凝固（p = 0.001）显着增加。与大小（p = 0.277），乳头状结构（p = 0.062）和等级（p = 0.578）没有显着相关性。结论：根据我们的研究结果，P53染色可作为区分恶性卵巢上皮性肿瘤的分界线的有用方法，尤其是在> 50％的细胞中表达有利于恶性的方式。

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