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首页> 外文期刊>Journal of Microbiology, Biotechnology and Food Sciences >CADMIUM AND DIAZINON-INDUCED CHANGES IN THE RAT TESTIS STRUCTURE AFTER A PERORAL ADMINISTRATION IN DRIKING WATER
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CADMIUM AND DIAZINON-INDUCED CHANGES IN THE RAT TESTIS STRUCTURE AFTER A PERORAL ADMINISTRATION IN DRIKING WATER

机译：饮水经口给药后大鼠睾丸结构中镉和重氮的变化

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The present study was carried out to elucidate the effects of heavy metal cadmium (Cd) and a nonselective organophosphorus insecticide diazinon (DZN) administration on the testis structures in adult male rats in subchronic toxicity experiments. A total of 40 Wistar 4 weeks old rats were randomized into 4 groups of 10 animals each and dosed with cadmium (Cd) 30 mg/l (group A), diazinon (DZN) 40 mg/l (group B), and in combination of Cd and DZN (30 and 40 mg/l, respectively, group C) per os in drinking water for 90 days. Testicular histology using a light microscopy and morphometry using PC morphometric software M.I.S. Quick Photo were evaluated. The morphometric data supported histological observations at tubular and interstitial level. Reduced seminiferous epithelium (P<0.001) in Cd group showed desquamation of germ cells, cellular degeneration and necrosis. Increase in epithelial vacuoles and dilated blood vessels relative volume (P<0.001) were observed in all experimental groups. Cd and DZN and their combination exerted changes in the reproductive parameters which could be subsequently negatively related to male fertility. These data provide a novel insight into the reproductive toxicology of Cd-DZN in male rats. However, results did not indicate synergistic or additional effect of simultaneous administration of both toxicants.
机译：本研究旨在阐明亚慢性毒性实验中重金属镉（Cd）和非选择性有机磷杀虫剂二嗪农（DZN）施用对成年雄性大鼠睾丸结构的影响。将总共​​40只4周龄的Wistar大鼠随机分为4组，每组10只动物，并分别以30 mg / l的镉（Cd）（A组），二嗪农（DZN）40 mg / l的剂量（B组）给药口服90天的os和Cd和DZN（分别为C组30和40 mg / l）。使用光学显微镜的睾丸组织学和使用PC形态分析软件M.I.S.快速照片进行了评估。形态学数据支持肾小管和间质水平的组织学观察。 Cd组生精上皮细胞减少（P <0.001），显示生殖细胞脱落，细胞变性和坏死。在所有实验组中观察到上皮液泡和血管相对体积的增加（P <0.001）。镉和DZN及其组合在生殖参数上产生变化，这些变化随后可能与男性生育力呈负相关。这些数据为雄性大鼠中Cd-DZN的生殖毒理学提供了新的见识。但是，结果并未显示同时施用两种毒物的协同作用或附加作用。

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