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首页> 外文期刊>Journal of nanomaterials >Effect of Orally Administered Glutathione-Montmorillonite Hybrid Systems on Tissue Distribution
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Effect of Orally Administered Glutathione-Montmorillonite Hybrid Systems on Tissue Distribution

机译：口服谷胱甘肽-蒙脱土混合体系对组织分布的影响

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摘要

An ubiquitous tripeptide, glutathione (GSH), is assigned a role in detoxification, activation of immune system, intermediary metabolism, transport, and protection of cells against free radicals or reactive oxygen species. However, instability of orally administered GSH in gastrointestinal (GI) tract leads to low absorption and low bioavailability in tissues. In this study, we attempted to synthesize GSH-montmorillonite (MMT) hybrid systems by intercalating GSH into the interlayers of a cationic clay delivery carrier, MMT, to improve GSH bioavailability at the systemic level. Polymer coating of the hybrid with polyvinylacetal diethylaminoacetate (AEA) was further performed to obtain better stability. Synthetic condition of both GSH-MMT and AEA-GSH-MMT hybrids was optimized, and then GSH-delivery efficiency was evaluated in various organs after oral administration in normal as well as GSH-deficient mice. The present GSH-MMT hybrids remarkably enhanced GSH concentration in the plasma, heart, kidney, and liver, especially when AEA-GSH-MMT hybrid was administered under GSH-deficient condition. Moreover, both hybrids did not induce acute oral toxicity up to 2000 mg/kg, suggesting their great potential for pharmaceutical application.
机译：普遍存在的三肽谷胱甘肽（GSH）在排毒，免疫系统激活，中间代谢，运输和保护细胞免受自由基或活性氧的作用中发挥作用。但是，胃肠道（GI）口服GSH的不稳定性导致组织中的吸收低和生物利用度低。在这项研究中，我们试图通过将GSH插入阳离子粘土输送载体MMT的中间层中来合成GSH蒙脱石（MMT）杂化体系，以提高全身水平的GSH生物利用度。进一步用聚乙烯醇缩醛二乙基氨基乙酸酯（AEA）对杂化物进行聚合物涂覆，以获得更好的稳定性。优化了GSH-MMT和AEA-GSH-MMT杂种的合成条件，然后在正常和GSH缺陷小鼠口服后评估了各器官中GSH的传递效率。本发明的GSH-MMT杂种显着提高了血浆，心脏，肾脏和肝脏中的GSH浓度，尤其是当在GSH缺乏的情况下施用AEA-GSH-MMT杂种时。此外，两种杂种都没有引起高达2000μmg/ kg的急性口服毒性，表明它们在药物应用方面具有巨大潜力。

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