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首页> 外文期刊>Journal of Molecular Biology Research >The Synthesis and Characterizes of Nano-Metallic Particles Against Antibiotic Resistant Bacteria, Isolated from Rasoul-e-Akram Hospital’s Patients, Tehran, Iran
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The Synthesis and Characterizes of Nano-Metallic Particles Against Antibiotic Resistant Bacteria, Isolated from Rasoul-e-Akram Hospital’s Patients, Tehran, Iran

机译：从伊朗德黑兰Rasoul-e-Akram医院的患者中分离出的纳米金属颗粒抗抗生素细菌的合成和表征

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The emergence of antimicrobial resistance of microorganisms to antibiotics, Also, an increase in nosocomial infections, particularly by Methicillin Resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, the need to discover new antibacterial agents with a mechanism of action different from killing bacteria were more than ever before. The Ag nanoparticles (NPs), ZnO (NPs) and Ag/ZnO (NPs) were synthesized through the thermal decomposition of the precursor of oxalate. Gram-negative antibiotic resistant bacteria and Gram-positive antibiotic resistant bacteria were prepared from the Central laboratory of Rasoul-e-Akram hospital. All of isolates were confirmed by biochemical tests. For determine of antibiotic resistance patterns of isolated, disk diffusion method in accordance with the standard CLSI were used, again. Antibacterial effects of (NPs) against antibiotic resistance bacteria were conducted by MIC and MBC tests. The particles size was less of 50 nm, approximately. Curiously, the silver (NPs) was not exposed the antibacterial properties against all of isolated bacteria. Also, klebsiella pneumonia and MRSA had greatest sensitivity to the ZnO (NPs). Also, Gram-positive antibiotic resistant bacteria showed high sensitivity to Ag/ZnO (NPs), compared to other bacteria. Interestingly, The MBC for ZnO (NPs) against Pseudomonas aeruginosa = 8192 was observed. The Ag (NPs) had not the ability to inhibit the nosocomial infection. klebsiella pneumonia and MRSA had greatest sensitivity to the ZnO (NPs). Also, Gram-positive antibiotic-resistant bacteria showed high sensitivity to Ag/ZnO (NPs), compared to other bacteria. The Ag/ZnO (NPs) was ability to kill antibiotics resistant bacteria. The antibacterial agents can open a new leaf in our life in the treatment of nosocomial infections.
机译：微生物对抗生素的抗药性的出现，此外，医院感染的增加，特别是耐甲氧西林金黄色葡萄球菌（MRSA），铜绿假单胞菌的感染，发现新的抗菌剂的作用机制与杀死细菌不同的需求远远超过了以往。通过草酸盐前体的热分解合成了Ag纳米颗粒（NPs），ZnO（NPs）和Ag / ZnO（NPs）。革兰氏阴性抗生素抗性细菌和革兰氏阳性抗生素抗性细菌是从Rasoul-e-Akram医院的中央实验室制备的。所有分离物均通过生化测试确认。为了确定分离出的抗生素抗性模式，再次使用了根据标准CLSI的圆盘扩散法。 （NP）对抗生素抗性细菌的抗菌作用通过MIC和MBC测试进行。粒度大约小于50nm。奇怪的是，银（NPs）并未暴露出对所有分离细菌的抗菌特性。另外，克雷伯菌肺炎和MRSA对ZnO（NPs）的敏感性最高。此外，与其他细菌相比，革兰氏阳性抗生素抗性细菌对Ag / ZnO（NPs）的敏感性更高。有趣的是，观察到针对铜绿假单胞菌的ZnO（NPs）的MBC> = 8192。 Ag（NPs）没有抑制医院感染的能力。克雷伯菌肺炎和MRSA对ZnO（NPs）的敏感性最高。此外，与其他细菌相比，革兰氏阳性抗生素抗性细菌对Ag / ZnO（NPs）表现出高敏感性。 Ag / ZnO（NPs）具有杀死抗药性细菌的能力。抗菌剂可以治疗我们的医院感染，为我们的生活打开新的一页。

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