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首页> 外文期刊>Journal of Molecular Genetics >Characterization of Myostatin (MSTN) Gene in Rabbit
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Characterization of Myostatin (MSTN) Gene in Rabbit

机译：兔肌肉生长抑制素（MSTN）基因的表征

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摘要

Three exonic regions of MSTN gene was resequenced in hundred rabbits (Oryctolagus cuniculus) of five different breeds viz.,White Giant, Grey Giant, Soviet Chinchilla, New Zealand White and Angora) to make comparative study. The comparison of three MSTN exonic region of these animals revealed in total four polymorphisms of which three were located in the exon I (g.108T>C, g.111C>G, g.247C>A) and one was located in exon II (g.711T>A), respectively. Among those identified polymorphisms only g.247C>A observed to be missense mutation which changes p.K83Q (Lysine to Glutamate) at the amino acid level. The mutation at the position g.247C>A was further analysed with PANTHER, cSNP and SNAP tool and considered for correlation with the production traits. In the analysis 92% of the White Giant rabbits were heterozygous for the identified mutation (g.247C>A), rest 8% of White Giant and all other breeds under study showed g.247A>A genotype. The phenotypic analysis inferred that White Giant had better performance (body weight) than the other breeds, i.e., Grey Giant, Soviet Chinchilla, New Zealand White and Angora.
机译：在五个不同品种的百只兔子中对MSTN基因的三个外显子区域进行了重测序，分别是白巨人，灰巨人，苏维奇龙猫，新西兰白和安哥拉。比较这些动物的三个MSTN外显子区域，发现总共有四个多态性，其中三个位于外显子I（g.108T> C，g.111C> G，g.247C> A），一个位于外显子II。 （g.711T> A）。在那些鉴定出的多态性中，仅观察到g.247C> A是错义突变，其在氨基酸水平上改变了p.K83Q（赖氨酸至谷氨酸）。用PANTHER，cSNP和SNAP工具进一步分析g.247C> A位置的突变，并考虑与生产性状的相关性。在分析中，有92％的白色巨人兔子的突变为纯合子（g.247C> A），其余8％的白色巨人和其他所有研究品种显示g.247A> A基因型。通过表型分析推断，白巨人的体能（体重）优于其他品种，即灰巨人，苏维埃龙猫，新西兰白和安哥拉。

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