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首页> 外文期刊>Journal of Neural Transplantation and Plasticity: Neural Plasticity >Motor Improvement of Skilled Forelimb Use Induced by Treatment with Growth Hormone and Rehabilitation Is Dependent on the Onset of the Treatment after Cortical Ablation
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Motor Improvement of Skilled Forelimb Use Induced by Treatment with Growth Hormone and Rehabilitation Is Dependent on the Onset of the Treatment after Cortical Ablation

机译：生长激素治疗和康复所致运动前肢使用技巧的改善取决于皮层消融后治疗的开始

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We previously demonstrated that the administration of GH immediately after severe motor cortex injury, in rats, followed by rehabilitation, improved the functionality of the affected limb and reexpressed nestin in the contralateral motor cortex. Here, we analyze whether these GH effects depend on a time window after the injury and on the reexpression of nestin and actin. Injured animals were treated with GH (0.15 mg/kg/day) or vehicle, at days 7, 14, and 35 after cortical ablation. Rehabilitation was applied at short and long term (LTR) after the lesion and then sacrificed. Nestin and actin were analyzed by immunoblotting in the contralateral motor cortex. Giving GH at days 7 or 35 after the lesion, but not 14 days after it, led to a remarkable improvement in the functionality of the affected paw. Contralateral nestin and actin reexpression was clearly higher in GH-treated animals, probably because compensatory brain plasticity was established. GH and immediate rehabilitation are key for repairing brain injuries, with the exception of a critical time period GH treatment starting 14 days after the lesion. Our data also indicate that there is not a clear plateau in the recovery from a brain injury in agreement with our data in human patients.
机译：我们先前证明严重的运动皮质损伤后立即在大鼠中施用GH，然后进行康复，可以改善患肢的功能并在对侧运动皮质中重新表达巢蛋白。在这里，我们分析这些GH效应是否取决于损伤后的时间窗以及nestin和actin的重新表达。在皮层消融后的第7、14和35天，用GH（0.15 mg / kg /天）或溶媒治疗受伤的动物。病变后短期和长期（LTR）进行修复，然后处死。通过对侧运动皮层的免疫印迹分析了巢蛋白和肌动蛋白。在病变后第7或35天（但不是在病变后14天）给予GH，可显着改善患处的爪子功能。在生长激素治疗的动物中，对侧巢蛋白和肌动蛋白的表达明显更高，这可能是因为建立了代偿性大脑可塑性。 GH和立即康复是修复脑损伤的关键，除了在病变后14天开始的关键时期GH治疗外。我们的数据还表明，与人类患者的数据相符，脑损伤的恢复尚无明显的平稳期。

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