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首页> 外文期刊>Journal of Natural Sciences Research >Correlation of histological changes with IgG and thyroid hormone concentrations in nodular toxic goiter patient's.
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Correlation of histological changes with IgG and thyroid hormone concentrations in nodular toxic goiter patient's.

机译：结节性甲状腺肿甲状腺肿患者组织学变化与IgG和甲状腺激素浓度的关系。

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Background : Thyroid disease includes many physiological disorders Toxic nodular goiter one of these disease involves an enlarged thyroid gland that reflex?rounded growths called nodules. These nodules is abnormal and produce too much thyroid hormone. Methods: This study was conducted to determinate the macroscopical and microscopical changes occurring in thyroid gland affected with toxic nodular goiter of both sexes, males and females. A total number of patients was 80 patients. 15 patients out of 80 were affected with nodular toxic goiter (2 male and 13 female). Results: Macroscopical examination showed the presence of mono and multinodular lesion with hypertrophy of some follicles and atrophy for other. Calcifications, haemorrhage, bundles of fibers were found with the matrix of thyroid tissues. Concerning microscopical examinations, it had been found that appearance of lymphoid nodules, cellular hypertrophy, hyperplasia and increase number of follicles cysts. Measurements of epithelium, colloid and follicles diameter were significantly (P<0.05) taller than healthy tissues. These changes might be attributed to continuous stimulating effects of thyroid which interne increase the activity of gland and tissues hypertrophied. Conclusion :Presence of various form of toxic goiter nodules correlated with many histological and hormonal alterations in addition to enhancements of antibody concentration .
机译：背景：甲状腺疾病包括许多生理性疾病中毒性结节性甲状腺肿是其中一种疾病，它涉及甲状腺肿大，反射性增生，称为结节。这些结节异常并产生过多的甲状腺激素。方法：本研究旨在确定在男性和女性的毒性结节性甲状腺肿影响的甲状腺中发生的宏观和微观变化。患者总数为80例。 80例中有15例受到结节性甲状腺肿的影响（男2例，女13例）。结果：肉眼检查发现存在单个和多结节病变，某些卵泡肥大，另一些卵泡萎缩。发现钙化，出血，纤维束与甲状腺组织基质有关。关于显微镜检查，已发现淋巴结节的出现，细胞肥大，增生和卵泡囊肿数量增加。上皮，胶体和卵泡直径的测量值明显高于健康组织（P <0.05）。这些变化可能归因于甲状腺的持续刺激作用，这会增加甲状腺和肥大组织的活性。结论：除了提高抗体浓度外，各种形式的毒性甲状腺肿结节的存在还与许多组织学和激素变化有关。

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