• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Molecular Biochemistry >GRP78 expression in canine mammary tumors: association with malignancy
【24h】

GRP78 expression in canine mammary tumors: association with malignancy

机译：GRP78在犬乳腺肿瘤中的表达：与恶性肿瘤的关系。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

78-kDa glucose-regulated protein (GRP78) is over-expressed in human breast carcinomas. GRP78 expression was studied in 40 spontaneous canine mammary tumors and evaluated in relation to tumor histological type, mode of growth, grade, lymph node metastases and distant metastases. All tumors exhibited GRP78 immunostaining. In the normal canine mammary gland, GRP78 was also expressed although not in all cases. In carcinomas GRP78 was detected in the cytoplasm in more than 50% of tumor cells in the vast majority of cases (87.5%). There was a significant association between the absence of squamous differentiation (P?=?0.02) and GRP78 over-expression, but no association with other clinico-pathological features. GRP78 was often co-expressed with galectin-3 in canine mammary tumors (CMT).
机译：78 kDa葡萄糖调节蛋白（GRP78）在人类乳腺癌中过表达。在40例自发性犬乳腺肿瘤中研究了GRP78的表达，并评估了其与肿瘤组织学类型，生长方式，等级，淋巴结转移和远处转移的关系。所有肿瘤均表现出GRP78免疫染色。在正常犬的乳腺中，尽管并非在所有情况下都表达了GRP78。在癌症中，绝大多数情况下，超过50％的肿瘤细胞在细胞质中检测到GRP78（87.5％）。鳞状上皮的缺乏与否（P？=？0.02）与GRP78过表达之间存在显着相关性，但与其他临床病理特征无关。在犬乳腺肿瘤（CMT）中，GRP78通常与半乳凝素3共表达。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号