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首页> 外文期刊>Journal of neuroinflammation >Reduction of microglial activity in a model of multiple sclerosis by dipyridamole
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Reduction of microglial activity in a model of multiple sclerosis by dipyridamole

机译：潘生丁降低多发性硬化模型中的小胶质细胞活性

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Background Despite extensive and persistent activation of microglia in multiple sclerosis (MS), microglia inhibitors have not yet been identified for treatment of the disorder. We sought to identify medications already in clinical use that could inhibit the activation of microglia. On the basis of the reported inhibitory effects of dipyridamole on phosphodiesterase activity that result in the production of various anti-inflammatory outcomes, we selected it for study. Dipyridamole is used clinically for secondary prevention in stroke. In this study, dipyridamole was examined using microglia in culture and in the mouse model of MS, experimental autoimmune encephalomyelitis (EAE). Results We found that dipyridamole attenuated the elevation of several cytokines and chemokines in human microglia caused by Toll-like receptor stimulation. Morphological characteristics of activated microglia in culture were also normalized by dipyridamole. In mice, dipyridamole decreased the clinical severity of EAE and reduced microglial activity and other histological indices of EAE in the spinal cord. Conclusions Dipyridamole is an inhibitor of microglia activation and may have a role in MS and other neurological conditions to attenuate microglial activity.
机译：背景技术尽管在多发性硬化症（MS）中小胶质细胞广泛且持续地活化，但尚未鉴定出用于治疗该疾病的小胶质细胞抑制剂。我们试图确定已经在临床使用的药物，可以抑制小胶质细胞的激活。根据已报告的双嘧达莫对磷酸二酯酶活性的抑制作用，该抑制作用导致产生各种抗炎作用，我们选择了其进行研究。双嘧达莫在临床上用于中风的二级预防。在这项研究中，使用培养的小胶质细胞和在MS小鼠模型（实验性自身免疫性脑脊髓炎（EAE））中检测了双嘧达莫。结果我们发现双嘧达莫可减轻由Toll样受体刺激引起的人类小胶质细胞中几种细胞因子和趋化因子的升高。双嘧达莫还可以使培养的活化小胶质细胞的形态学特征正常化。在小鼠中，潘生丁降低了脊髓的EAE的临床严重程度，并降低了小胶质细胞活性和EAE的其他组织学指标。结论双嘧达莫是小胶质细胞活化的抑制剂，可能在MS和其他神经系统疾病中减弱小胶质细胞的活性。

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