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首页> 外文期刊>Journal of Neurodegenerative Diseases >Immunolocalization of Kisspeptin Associated with Amyloid-β Deposits in the Pons of an Alzheimer’s Disease Patient
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Immunolocalization of Kisspeptin Associated with Amyloid-β Deposits in the Pons of an Alzheimer’s Disease Patient

机译：阿尔茨海默氏病患者脑桥中与淀粉样蛋白β沉积有关的kisseptin的免疫定位

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The pons region of the Alzheimer’s disease (AD) brain is one of the last to show amyloid-β (Aβ) deposits and has been suggested to contain neuroprotective compounds. Kisspeptin (KP) is a hormone that activates the hypothalamic-pituitary-gonadal axis and has been suggested to be neuroprotective against Aβ toxicity. The localization of KP, plus the established endogenous neuroprotective compounds corticotropin releasing hormone (CRH) and catalase, in tissue sections from the pons region of a male AD subject has been determined in relation to Aβ deposits. Results showed Aβ deposits also stained with KP, CRH, and catalase antibodies. At high magnification the staining of deposits was either KP or catalase positive, and there was only a limited area of the deposits with KP-catalase colocalization. The CRH does not bind Aβ, whilst both KP and catalase can bind Aβ, suggesting that colocalization in Aβ deposits is not restricted to compounds that directly bind Aβ. The neuroprotective actions of KP, CRH, and catalase were confirmed in vitro, and fibrillar Aβ preparations were shown to stimulate the release of KP in vitro. In conclusion, neuroprotective KP, CRH, and catalase all colocalize with Aβ plaque-like deposits in the pons region from a male AD subject.
机译：阿尔茨海默氏病（AD）大脑的脑桥区域是最后一个显示淀粉样β（Aβ）沉积的区域之一，并且已被建议包含神经保护化合物。 Kisspeptin（KP）是一种激活下丘脑-垂体-性腺轴的激素，并已被证明对Aβ毒性具有神经保护作用。相对于Aβ沉积物，已经确定了KP的位置，以及已建立的内源性神经保护化合物促肾上腺皮质激素释放激素（CRH）和过氧化氢酶，位于男性AD受试者脑桥区域的组织切片中。结果显示，Aβ沉积物也被KP，CRH和过氧化氢酶抗体染色。在高放大倍数下，沉积物的染色呈KP或过氧化氢酶阳性，并且只有有限区域的沉积物带有KP-过氧化氢酶共定位。 CRH不结合Aβ，而KP和过氧化氢酶都可以结合Aβ，这表明Aβ沉积物中的共定位作用不限于直接结合Aβ的化合物。在体外证实了KP，CRH和过氧化氢酶的神经保护作用，并且显示了原纤维Aβ制剂在体外刺激了KP的释放。总之，神经保护性KP，CRH和过氧化氢酶均与男性AD患者脑桥区域Aβ斑块状沉积物共定位。

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