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首页> 外文期刊>Journal of NeuroEngineering Rehabilitation >An overview of tissue engineering approaches for management of spinal cord injuries
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An overview of tissue engineering approaches for management of spinal cord injuries

机译：组织工程学方法治疗脊髓损伤的概述

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摘要

Severe spinal cord injury (SCI) leads to devastating neurological deficits and disabilities, which necessitates spending a great deal of health budget for psychological and healthcare problems of these patients and their relatives. This justifies the cost of research into the new modalities for treatment of spinal cord injuries, even in developing countries. Apart from surgical management and nerve grafting, several other approaches have been adopted for management of this condition including pharmacologic and gene therapy, cell therapy, and use of different cell-free or cell-seeded bioscaffolds. In current paper, the recent developments for therapeutic delivery of stem and non-stem cells to the site of injury, and application of cell-free and cell-seeded natural and synthetic scaffolds have been reviewed.
机译：严重的脊髓损伤（SCI）导致严重的神经功能缺损和残疾，这需要花费大量的健康预算来解决这些患者及其亲属的心理和医疗保健问题。即使在发展中国家，这也证明了研究治疗脊髓损伤的新方法的成本是合理的。除了手术管理和神经移植以外，还采用了其他几种方法来管理这种疾病，包括药物治疗和基因治疗，细胞治疗以及使用不同的无细胞或接种细胞的生物支架。在当前的论文中，对干细胞和非干细胞治疗性递送至损伤部位的最新进展以及无细胞和细胞接种的天然和合成支架的应用进行了综述。

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