Langerhans’ Cells may linked to neuro-immuno-modulation

Nezih OKTAR

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Langerhans’ Cells may linked to neuro-immuno-modulation

机译：朗格汉斯细胞可能与神经免疫调节有关

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The cutaneous cells bearing Paul Langerhans’ eponym were first described by him in 1868. These cells have remained mysterious for a very long time; as late as 1974, Montagna and Parakkal could state that “their origin remains somewhat obscure and their function is completely unknown.” Langerhans’ cells (LC) play an important role in the induction of contact hypersensitivity and graft rejection. These antigen presenting cells are modulated by various physicochemical agents (such as UV light, in my opinion acupuncture) and can be infected by the AIDS virus. Recent studies also reveal that cytokines mediate their development into potent T cell-stimulatory dendritic cells. Thus, we may well use LC for stimulating nervous system regulatory network as Paul Langerhans stated almost 140 years ago.

机译：保罗·朗格汉斯（Paul Langerhans）同名的皮肤细胞最早是在1868年由他描述的。直到1974年，蒙塔尼亚（Montagna）和帕拉卡（Parakkal）都可以说“它们的起源仍然模糊不清，其功能完全未知”。朗格汉斯细胞（LC）在诱导接触性超敏反应和移植物排斥中起重要作用。这些抗原呈递细胞受到各种物理化学试剂（例如，我认为是针灸，例如紫外线）的调节，并可能被艾滋病病毒感染。最近的研究还表明，细胞因子介导其发展为有效的T细胞刺激性树突状细胞。因此，正如保罗·朗格汉斯（Paul Langerhans）差不多140年前所说，我们很可能会使用LC来刺激神经系统调节网络。

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《Journal of neurological sciences (Turkish)》 |2007年第1期|共4页
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Nezih OKTAR;
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中图分类神经病学与精神病学;
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1. Langerhans’ cell histiocytosis diagnosed due to dermatological perianal lesion [J] . Scolaro Bruno Lorenzo, Pereira Gustavo Becker, Ogata Daniel Cury, Revista Brasileira de Colo-Proctologia : orgao oficial . 2017,第3期

机译：皮肤科肛周病变诊断出朗格汉斯细胞组织细胞增生症
2. The Linker for Activation of B Cells (LAB)/Non-T Cell Activation Linker (NTAL) Regulates Triggering Receptor Expressed on Myeloid Cells (TREM)-2 Signaling and Macrophage Inflammatory Responses Independently of the Linker for Activation of T Cells [J] . Gillian Whittaker, Selinda Orr, Laura Quigley, The Journal of biological chemistry . 2010,第5期

机译：用于激活B细胞的接头（实验室）/非T细胞活化接头（NTAL）调节在骨髓细胞（TREM）-2信号传导和巨噬细胞炎症反应的触发受体，与用于激活T细胞的接头
3. Analysis of the linker for activation of T cells and the linker for activation of B cells in natural killer cells reveals a novel signaling cassette, dual usage in ITAM signaling, and influence on development of the Ly49 repertoire. [J] . Whittaker GC, Burshtyn DN, Orr SJ, Blood: The Journal of the American Society of Hematology . 2008,第7期

机译：对天然杀伤细胞中激活T细胞的接头和激活B细胞的接头的分析揭示了一种新颖的信号盒，在ITAM信号中具有双重用途，并影响Ly49分子库的发育。
4. Cross-linking Peptide Vaccine Heat Shock Protein 72 and Alpha-fetoprotein Elicited Specific Dendritic Cells, Cytotoxic T-lymphocyte Cells and Natural Killing Cells [C] . Xiao-Ping WANG, Bing XU, Huan-Ping LIN, International Conference on Materials Science and Application . 2015

机译：交联肽疫苗热休克蛋白72和α-胎蛋白引发特异性树突细胞，细胞毒性T淋巴细胞细胞和天然杀伤细胞
5. Effect of extracellular pH, ammonia, and cell aggregation on the specific expression rate and N-linked glycosylation of recombinant mouse-placental lactogen proteins by Chinese hamster ovary (CHO) cells. [D] . Borys, Michael Christopher. 1993

机译：细胞外pH，氨和细胞聚集对中国仓鼠卵巢（CHO）细胞重组小鼠胎盘泌乳原蛋白特异性表达率和N联糖基化的影响。
6. The Linker for Activation of B Cells (LAB)/Non-T Cell Activation Linker (NTAL) Regulates Triggering Receptor Expressed on Myeloid Cells (TREM)-2 Signaling and Macrophage Inflammatory Responses Independently of the Linker for Activation of T Cells [O] . Gillian C. Whittaker, Selinda J. Orr, Laura Quigley, 2010

机译：B细胞活化连接子（LAB）/非T细胞活化连接子（NTAL）独立于T细胞活化连接子调节在髓样细胞（TREM）-2信号和巨噬细胞炎症反应中表达的触发受体
7. The Linker for Activation of B Cells (LAB)/Non-T Cell Activation Linker (NTAL) Regulates Triggering Receptor Expressed on Myeloid Cells (TREM)-2 Signaling and Macrophage Inflammatory Responses Independently of the Linker for Activation of T Cells* [O] . Whittaker, Gillian C., Orr, Selinda J., Quigley, Laura, 2009

机译：B细胞活化连接子（LAB）/非T细胞活化连接子（NTAL）独立于T细胞活化连接子来调节髓样细胞（TREM）-2信号和巨噬细胞炎症反应表达的触发受体*

Langerhans’ Cells may linked to neuro-immuno-modulation

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