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首页> 外文期刊>Journal of Mid-Life Health >Extensively metastasizing leiomyosarcoma: A diagnostic challenge
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Extensively metastasizing leiomyosarcoma: A diagnostic challenge

机译：广泛转移性平滑肌肉瘤：诊断上的挑战

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Uterine leiomyosarcoma (ULMS) is a rare malignancy of the female genital tract and carries an extremely poor 5-year survival rate. It is known to metastasize early and to distant sites owing to a high propensity for hematogeneous spread. Lung, peritoneum, liver, and bone are relatively common sites of metastasis. Patient age, tumor size, FIGO stage, and grade of the tumor are important criteria for predicting metastasis. The incidence of ULMS is increasing, probably due to the use of improved imaging techniques and as a result of cancer patients' prolonged life expectancy. An early well thought diagnosis is only made possible if even in otherwise seemingly unsuspected cases, the histopathology slides are extensively screened and the treating clinician is alerted timely. We hereby report a case of an elderly female who underwent hysterectomy for resection of multiple fibroids in the uterus and later presented with distant metastasis to brain with the erosion of overlying skull bone, chest wall, and lungs. Microscopic features along with an extensive immunohistochemistry panel were used to ascertain tumor origin.
机译：子宫平滑肌肉瘤（ULMS）是女性生殖道罕见的恶性肿瘤，其5年生存率极低。已知由于血行性传播的高倾向，其早期转移至远处。肺，腹膜，肝脏和骨骼是相对常见的转移部位。患者年龄，肿瘤大小，FIGO分期和肿瘤等级是预测转移的重要标准。 ULMS的发病率正在增加，这可能是由于使用了改进的成像技术以及癌症患者预期寿命延长的结果。只有在原本看似未曾预料的情况下，对组织病理学切片进行广泛筛查并及时提醒治疗的临床医生，才有可能进行早期的深思熟虑的诊断。我们在此报告一例老年女性，该女性接受子宫切除术以切除子宫中的多个肌瘤，随后由于颅骨，胸壁和肺部的侵蚀而向大脑转移。微观特征以及广泛的免疫组织化学方法被用于确定肿瘤起源。

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