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首页> 外文期刊>Journal of Neuroscience and Behavioral Health >Medication-related factors of non adherence among patients with schizophrenia and bipolar disorder: Outcome of a cross-sectional survey in Maiduguri, North-eastern Nigeria
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Medication-related factors of non adherence among patients with schizophrenia and bipolar disorder: Outcome of a cross-sectional survey in Maiduguri, North-eastern Nigeria

机译：精神分裂症和双相情感障碍患者中非依从性的药物相关因素：尼日利亚东北部迈杜古里（Maiduguri）的横断面调查结果

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Pharmacotherapy is the cornerstone in the symptomatic treatment of schizophrenia and bipolar disorder, but non-adherence to the medications constitutes major obstacles to optimal outcome in their management. This study assessed the prevalence of and exclusively x-rayed medication-related factors of non-adherence among patients with these disorders in a resource-poor setting. Three hundred and fifty eight (358) patients with schizophrenia and bipolar disorder were randomly enrolled and interviewed at the out-patient department of the Federal Neuropsychiatric Hospital, Maiduguri in North-eastern Nigeria. Data were collected using an anonymous sociodemographic questionnaire, clinical proforma and the Hausa version of the 8-item Morisky Medication Adherence Scale (MMAS-8). The overall prevalence of non-adherence was 54.2%, while the rates were 62.5% and 45.8% for subjects with schizophrenia and bipolar disorder respectively. The independent medication-related predictors of non-adherence were: multiple dosing frequency (Odds Ratio (O.R) = 7.843, 95% C.I = 4.537 to 13.557, P ≤ 0.001), presence of side effects (O.R = 6.823, 95% C.I = 3.900 - 11.937, p ≤ 0.001), cost of medications (O.R. = 4.009, 95% C.I = 2.555 to 6.921, p ≤ 0.001), and polytherapy (O.R. = 2.317, 95% C.I = 1.363 to 3.940, p = 0.002). This study therefore, recommends the use of guidelines that encourage rational pharmacotherapy based on monotherapy, consider routine lower dosing prescriptions, and integrating side effects surveillance and early intervention in clinical practice.
机译：药物疗法是精神分裂症和双相情感障碍对症治疗的基石，但不坚持药物治疗则是其最佳治疗效果的主要障碍。这项研究评估了资源贫乏地区这些疾病患者中非依从性的普遍存在和仅与X射线相关的药物相关因素。 358名（358）精神分裂症和躁郁症患者被随机纳入尼日利亚东北部Maiduguri联邦神经精神病医院的门诊部进行了访谈。使用匿名的社会人口统计学问卷，临床形式和8项Morisky药物依从性量表（MMAS-8）的Hausa版本收集数据。精神分裂症和双相情感障碍患者的总体不依从发生率为54.2％，而发生率分别为62.5％和45.8％。与药物治疗相关的非依从性独立预测因素为：多次给药频率（几率（OR）= 7.843，95％CI = 4.537至13.557，P≤0.001），是否存在副作用（OR = 6.823，95％CI = 3.900-11.937，p≤0.001），药物治疗费用（OR = 4.009，95％CI = 2.555至6.921，p≤0.001）和多药疗法（OR = 2.317，95％CI = 1.363至3.940，p = 0.002）。因此，本研究建议使用指导方针，以鼓励基于单一疗法的合理药物治疗，考虑常规低剂量处方以及将副作用监测和早期干预纳入临床实践。

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