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首页> 外文期刊>Journal of Neurosciences in Rural Practice >Autonomic dysfunction: A comparative study of patients with Alzheimer's and frontotemporal dementia – A pilot study
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Autonomic dysfunction: A comparative study of patients with Alzheimer's and frontotemporal dementia – A pilot study

机译：自主神经功能障碍：阿尔茨海默氏症和额颞痴呆患者的比较研究–一项初步研究

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Introduction: In frontotemporal dementia (FTD) and Alzheimer's disease (AD), central autonomic structures get affected early. An insight into autonomic functions in these patients is likely to be of diagnostic importance and thus help in prognosticating and also probably explain unexplained sudden death in some of these patients. Objectives: The objective of this study is to identify autonomic dysfunction prevailing in patients. Then, if there is dysfunction, is the pattern same or different in these two conditions. And if different it will serve as an additional biomarker for specific diagnosis. Patients and Methods: There were 25 patients and 25 controls and six patients and three controls in AD and FTD groups, respectively. The participants who were recruited were assessed for heart rate variability and conventional cardiac autonomic function testing. The parameters were analyzed using LabChart version 7 software and compared with control population using appropriate statistical methods using SPSS version 22 software. Results: The mean overall total power was low in the FTD group ( P < 0.001), and there was significant reduction in the standard deviation of normal-to-normal intervals and root mean square of successive differences ( P < 0.001) with elevated sympathovagal balance in the FTD group ( P = 0.04). Patients with AD also showed sympathetic dominance, but there was in addition parasympathetic suppression unlike in the FTD group. Conclusion: This study reveals autonomic dysfunction in patients with FTD and AD. Both conditions show sympathetic dominance, probably consecutive to the involvement of central autonomic regulatory structures as a shared domain. It remains to be confirmed if these findings are the cause or effect of neurodegeneration and might open up newer territories of research based on the causal role of neurotransmitters in these regions and thus lead to novel therapeutic options such as yoga. The presence of parasympathetic suppression in AD in addition helps differentiate these two conditions.
机译：简介：在额颞叶痴呆（FTD）和阿尔茨海默氏病（AD）中，中央自主神经结构会受到早期影响。了解这些患者的自主神经功能可能具有诊断意义，因此有助于预后，也可能解释了其中一些患者无法解释的猝死。目的：本研究的目的是确定患者中普遍存在的自主神经功能障碍。然后，如果存在功能障碍，这两种情况下的模式是相同还是不同。如果不同，它将用作特定诊断的附加生物标记。患者和方法：AD和FTD组分别有25例患者和25例对照，以及6例患者和3例对照。招募的参与者进行了心率变异性和常规心脏自主神经功能测试的评估。使用LabChart 7版软件分析参数，并使用SPSS 22版软件使用适当的统计方法与对照组进行比较。结果：FTD组的平均总总功率较低（P <0.001），交感迷走神经升高的正常至正常间隔的标准偏差和连续差异的均方根（P <0.001）显着降低FTD组中的余额（P = 0.04）。 AD患者也表现出交感优势，但与FTD组不同，还存在副交感抑制。结论：这项研究揭示了FTD和AD患者的自主神经功能障碍。两种情况都显示出同情的优势，可能是中央自主调节结构作为共享域的连续发生。这些发现是否是神经退行性疾病的原因或结果还有待证实，并可能基于这些区域中神经递质的因果作用开辟新的研究领域，从而导致新的治疗选择，例如瑜伽。 AD中副交感神经抑制的存在还有助于区分这两种情况。

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