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首页> 外文期刊>Journal of Ophthalmic Inflammation and Infection >Importance of proper diagnosis for management: multifocal choroiditis mimicking ocular histoplasmosis syndrome
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Importance of proper diagnosis for management: multifocal choroiditis mimicking ocular histoplasmosis syndrome

机译：正确诊断管理的重要性：模仿眼组织胞浆菌病综合征的多灶性脉络膜炎

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The study aims to evaluate a series of patients with initial diagnosis of ocular histoplasmosis syndrome (OHS) with progression and response to treatments consistent with multifocal choroiditis (MFC). Retrospective review of nine patients referred for management of recurrent OHS lesions. Serology panel was conducted to rule out autoimmune and infectious causes. Clinical examination revealed multiple small, punched-out peripheral chorioretinal scars, and peripapillary atrophy. Histoplasma antigen/antibody was negative in all patients. Fluorescein angiography and optical coherence tomography confirmed active inflammation in five patients. Immunomodulatory therapy (IMT) was initiated to control active inflammation. While on IMT, visual acuity stabilized or improved in three patients with no recurrence of CNV or lesion activities over the follow-up period. MFC may initially masquerade as OHS. Clinical characteristics of recurrent MFC and absence of histoplasma titer may lead to consideration of IMT and other proper treatments for MFC.
机译：这项研究旨在评估一系列初步诊断为眼组织胞浆菌病综合征（OHS）的患者，其进展和对与多灶性脉络膜炎（MFC）一致的治疗的反应。回顾性分析9例复发性OHS病变的治疗患者。进行血清学检查以排除自身免疫和感染原因。临床检查发现周围有多个小的穿孔性脉络膜视网膜瘢痕和乳头周围萎缩。所有患者的组织浆抗原/抗体均为阴性。荧光素血管造影和光学相干断层扫描证实了五名患者的活动性炎症。发起免疫调节疗法（IMT）以控制活动性炎症。在IMT期间，三位患者的视力稳定或改善，且在随访期间未复发CNV或病变。 MFC最初可能会伪装成OHS。复发性MFC的临床特征和组织胞浆滴度的缺失可能导致考虑使用IMT和其他合适的MFC治疗方法。

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