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首页> 外文期刊>Journal of Ophthalmology >Tear Ferning Test and Pathological Effects on Ocular Surface before and after Topical Cyclosporine in Vernal Keratoconjunctivitis Patients
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Tear Ferning Test and Pathological Effects on Ocular Surface before and after Topical Cyclosporine in Vernal Keratoconjunctivitis Patients

机译：春季角结膜炎患者局部用环孢菌素前后眼泪撕裂试验及其对眼表的病理影响

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Background. Vernal keratoconjunctivitis (VKC) is a rare ocular surface inflammatory disease that affects mainly boys in the first decade of life. Clinical observations show that it generally regresses spontaneously with the onset of puberty, but therapeutic measures must be taken before then to control the course of the disease. Purpose.To evaluate the role of the lacrimal mucous component in VKC patients and compare tear ferning test (TFT) modifications, MUC5AC levels in tears, and density of conjunctival goblet cells to clinical characteristics before and after treatment with cyclosporine A (CY) in eye drops. Methods. Forty-seven patients affected by VKC and 30 healthy subjects aged between 3 and 16 years of life were enrolled. All individuals were submitted to complete eye examination and skin prick test (SPT) for the most common allergens. Then, they were subjected to collection of the tears and to impression cytology to evaluate TFT, MUC5AC levels, and conjunctival goblet cell density, before and after treatment with CY in eye drops. Results. Comparing the VKC group vs. the control group at baseline, a significant alteration in the degree of the ferns was found, indicating a pathological condition of the lacrimal mucous layer. In addition, an increased number of goblet cells were observed in the patients. The concentration of lacrimal secretory mucins (MUC5AC) did not show significant differences between the 2 groups. Patients treated with CY have reported improvements of some signs and symptoms of disease activity, including TFT, and a tendency of conjunctival goblet cell density to normalise. Conclusions. The results obtained demonstrated for the first time a significant alteration of the lacrimal mucin component evaluated in the VKC group, and an improvement of the latter after CY therapy.
机译：背景。春季角膜结膜炎（VKC）是一种罕见的眼表炎性疾病，在生命的头十年中主要影响男孩。临床观察表明，它通常随着青春期的发作而自发消退，但是在此之前必须采取治疗措施以控制疾病的进程。目的：评估泪液粘膜成分在VKC患者中的作用，并比较眼泪经环孢素A（CY）治疗前后的泪液浸润试验（TFT）修饰，泪液中MUC5AC水平和结膜杯状细胞密度与临床特征的比较滴。方法。招募了47位受VKC影响的患者和30位3至16岁的健康受试者。所有个体均接受了最常见过敏原的完整眼检和皮肤点刺试验（SPT）。然后，在用CY滴眼液治疗前后，对他们进行眼泪收集和印模细胞学检查，以评估TFT，MUC5AC水平和结膜杯状细胞密度。结果。在基线时将VKC组与对照组进行比较，发现蕨类植物的程度发生了显着变化，表明泪液粘膜层的病理状况。另外，在患者中观察到杯状细胞数量增加。两组之间的泪液分泌粘蛋白（MUC5AC）浓度没有显示出显着差异。接受CY治疗的患者已报告疾病活动的某些体征和症状有所改善，包括TFT，以及结膜杯状细胞密度趋于正常的趋势。结论。获得的结果首次证明在VKC组中评估的泪液粘蛋白成分发生了显着改变，并且在CY治疗后后者得到了改善。

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