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首页> 外文期刊>Journal of Ophthalmology >Treatment of Diabetic Macular Edema with Intravitreal Antivascular Endothelial Growth Factor and Prompt versus Deferred Focal Laser during Long-Term Follow-Up and Identification of Prognostic Retinal Markers
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Treatment of Diabetic Macular Edema with Intravitreal Antivascular Endothelial Growth Factor and Prompt versus Deferred Focal Laser during Long-Term Follow-Up and Identification of Prognostic Retinal Markers

机译：长期随访期间玻璃体腔内抗血管内皮生长因子联合提示与延迟聚焦激光治疗糖尿病性黄斑水肿及视网膜标志物的鉴定

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Purpose. Long-term follow-up of patients with diabetic macular edema (DME) treated with intravitreal antivascular endothelial growth factor (anti-VEGF) combined focal laser and identification of prognostic morphological characteristics. Methods. Prospective clinical trial (50 treatment-naive eyes) with DME randomized 1??1 receiving intravitreal ranibizumab (0.5?mg/0.05?ml) and prompt grid laser compared with ranibizumab and deferred laser. Morphological characteristics potentially relevant for prognosis were assessed at baseline, month 6, month 9, and years 1, 2, 3, 4, and 5 of follow-up. Results. Although functional results were slightly higher in the prompt group at week 12 (0.5; 20/40 Snellen (SD?=?0.04, 0.3 logMAR) versus 0.4; 20/50 Snellen (SD?=?0.04, logMAR 0.4), ) and month 9 (prompt group 0.5; 20/40 Snellen (SD?=?0.03, 0.3 logMAR) versus deferred group 0.4; 20/50 Snellen (SD?=?0.04, 0.4 logMAR), ), these were statistically insignificant. There was no significant benefit regarding functionality during long-term follow-up in the prompt group compared to the deferred group. BCVA in the eyes with clusters of hyperreflective foci in the central macular region was inferior compared with the eyes without these alterations at year 5 (0.39; 20/50 Snellen, (SD?=?0.25, 0.4 logMAR) versus 0.63; 20/80 Snellen (SD?=?0.22, 0.2 logMAR), ). Conclusion. Grid laser and ranibizumab therapy are effective in DME management during the long-term follow-up. Intraretinal hyperreflective material in SD-OCT is negatively related to BCVA.
机译：目的。玻璃体腔内抗血管内皮生长因子（anti-VEGF）联合聚焦激光治疗的糖尿病性黄斑水肿（DME）患者的长期随访并鉴定预后的形态学特征。方法。前瞻性临床试验（50只未接受过治疗的眼睛）采用DME随机分配1？1接受玻璃体内兰尼单抗（0.5？mg / 0.05？ml）和及时栅格激光治疗，与兰尼单抗和递延激光比较。在基线，随访的第6个月，第9个月和第1、2、3、4和5年评估可能与预后相关的形态学特征。结果。尽管提示组在第12周的功能性结果略高（0.5; 20/40 Snellen（SD？=？0.04，0.3 logMAR）与0.4; 20/50 Snellen（SD？=？0.04，logMAR 0.4），）和第9个月（提示组0.5; 20/40 Snellen（SD = 0.03，0.3 logMAR）与延迟组0.4; 20/50 Snellen（SD = 0.04，0.4 logMAR），），这些在统计学上不显着。与推迟组相比，提示组在长期随访期间的功能没有显着优势。与没有这些改变的眼睛相比，在第5年时，具有黄斑中心区高反射灶簇的眼睛的BCVA较差（0.39; 20/50 Snellen，（SD？=？0.25，0.4 logMAR）对0.63; 20/80） Snellen（SD≥0.22，0.2logMAR），）。结论。在长期随访中，栅格激光和兰尼单抗治疗对DME管理有效。 SD-OCT中的视网膜内高反射材料与BCVA负相关。

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