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首页> 外文期刊>Journal of Ophthalmology >Effect of Intravitreal Ranibizumab in the Treatment of Peripapillary Choroidal Neovascularisation
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Effect of Intravitreal Ranibizumab in the Treatment of Peripapillary Choroidal Neovascularisation

机译：玻璃体腔内雷珠单抗治疗周围性乳头状脉络膜新生血管的作用

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Intravitreal ranibizumab therapy is widely used in treatment of subfoveal choroidal neovascularisation (CNV) in age-related macular degeneration. We wanted to study the effect of intravitreal ranibizumab therapy in peripapillary CNV. A prospective recording of treatment outcomes in twelve eyes (12 patients) with peripapillary CNV with intravitreal injections of ranibizumab was performed. The patients received a series of 3 injections 4–6 weeks apart, and then a new ophthalmic examination was made including OCT and further therapy was given if the peripapillary CNV was still active. Nine patients had idiopathic peripapillary CNV, and in 3 patients it was associated to age-related macular degeneration. Followup had to be at least 6 months. The mean follow-up time was 15.9 (range 9–27) months and the mean number of injections 6.2 (3–10). In 10 patients treatment had resulted in an inactivation of the peripapillary CNV, but 3 of them had reactivation, while 2 patients had no inactivation. Currently, 5 patients are continuous to receive treatment. VA improved in 10 patients. Intravitreal ranibizumab therapy appears to be effective in patients with peripapillary CNV, but in some cases there is repeated reactivation or continuous activity of the peripapillary CNV.
机译：玻璃体内兰尼单抗治疗被广泛用于治疗年龄相关性黄斑变性的中央凹脉络膜新生血管（CNV）。我们想研究玻璃体内兰尼单抗治疗在乳头周围CNV中的作用。前瞻性记录十二指肠周围CNV并玻璃体内注射兰尼单抗的治疗结果（12例）。患者间隔4-6周接受了3次注射，然后进行了一次新的眼科检查，包括OCT，如果乳头周围CNV仍然活跃，则应进行进一步治疗。 9例患者患有特发性乳头状周围CNV，其中3例患者与年龄相关的黄斑变性有关。随访时间至少为6个月。平均随访时间为15.9（9–27）个月，平均注射次数为6.2（3–10）。在10例患者中，治疗导致了乳头周围CNV失活，但是其中3例已经重新激活，而2例患者没有失活。目前，有5名患者正在连续接受治疗。 VA改善10例。玻璃体内兰尼单抗治疗似乎对患有乳头状CNV的患者有效，但是在某些情况下，乳头状CNV会反复激活或持续活动。

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