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首页> 外文期刊>Journal of Optometry >Retinal glial changes in Alzheimer's disease – A review
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Retinal glial changes in Alzheimer's disease – A review

机译：阿尔茨海默氏病的视网膜神经胶质变化–综述

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Alzheimer's disease (AD) is a neurodegenerative dementia characterized by the deposition of extracellular β-amyloid (Aβ) plaques and the presence of neurofibrillary tangles. Until now, the techniques used to analyze these deposits have been difficult to access, invasive, and expensive. This leads us to consider new access routes to the central nervous system (CNS), allowing us to diagnose the disease before the first symptoms appear. Recent studies have shown that microglial and macroglial cell activation could play a role in the development of this disease. Glial cells in the CNS can respond to various damages, such as neurodegenerative pathologies, with morphological and functional changes. These changes are a common feature in neurodegenerative diseases, including AD. The retina is considered an extension of the CNS and has a population of glial cells similar to that of the CNS. When glial cells are activated, various molecules are released and changes in glial cell expression occur, which can be indicators of neuronal damage. The objective of this review is to compile the most relevant findings in the last 10 years relating to alterations in the eye in AD, and the role that glial cells play in the degenerative process in the retina in the context of neurodegeneration.
机译：阿尔茨海默氏病（AD）是一种神经退行性痴呆，其特征在于细胞外β-淀粉样蛋白（Aβ）斑块的沉积和神经原纤维缠结的存在。到目前为止，用于分析这些矿床的技术一直很难获得，具有侵入性且昂贵。这使我们考虑了通向中枢神经系统（CNS）的新途径，从而使我们能够在出现最初症状之前就诊断出这种疾病。最近的研究表明，小胶质细胞和大胶质细胞的激活可能在这种疾病的发展中起作用。中枢神经系统中的神经胶质细胞可以通过形态和功能变化来响应各种损伤，例如神经退行性病变。这些改变是包括AD在内的神经退行性疾病的共同特征。视网膜被认为是中枢神经系统的延伸，并具有与中枢神经系统相似的神经胶质细胞。当神经胶质细胞被激活时，各种分子被释放并且神经胶质细胞表达发生变化，这可以指示神经元损伤。这篇综述的目的是收集最近十年与AD眼中的改变有关的最相关的发现，以及神经变性背景下神经胶质细胞在视网膜变性过程中所起的作用。

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