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Effect of phenylephrine on static and dynamic accommodation

机译：苯肾上腺素对静态和动态调节的影响

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Purpose We tested the hypothesis that changes in accommodation after instillation of Phenylephrine Hydrochloride (PHCl) observed in some studies could be caused by changes in optics. Methods We performed two experiments to test the effects of PHCl on static and on dynamic accommodation in 8 and 6 subjects, respectively. Objective wavefront measurements were recorded of the static accommodation response to a stimulus at different distances or dynamic accommodation response to a sinusoidally moving stimulus (between 1 and 3 D of accommodative demand at 0.2?Hz). The responses were characterized using two methods: one that takes into account the mydriatic optical effects on the accommodation produced by higher-order aberrations of the eye and another that takes into account only power changes paraxially due to the action of the ciliary muscle and regardless of the pupil size. Results When mydriatic optical effects were taken into account, differences in responses before and after PHCl instillation were 0.51±0.53 D, and 0.12±0.15, for static and dynamic accommodation, respectively, and were statistically significant ( p 0.039). When mydriatic optical effects were not taken into account, the differences in responses before and after PHCl instillation were ?0.20±0.51 D, and ?0.05±0.14, for static and dynamic accommodation, respectively, and were not statistically significant ( p 0.313). Conclusions The mydriatic effect of the PHCl causes optical changes in the eye that can reduce the objective and subjective measurement of accommodation.
机译：目的我们测试了以下假设：在某些研究中观察到滴注盐酸苯肾上腺素（PHCl）后适应性的变化可能是由光学器件的变化引起的。方法我们进行了两个实验，分别测试了PHCl对8名和6名受试者的静态和动态适应性的影响。记录客观波前测量值，以记录在不同距离处对刺激的静态适应响应或对正弦运动刺激的动态适应响应（0.2？Hz的1至3 D的适应性需求）。使用两种方法对响应进行了表征：一种方法考虑了散瞳对眼睛高阶像差产生的调节的光学影响，另一种方法仅考虑了由于睫状肌的作用而引起的近轴功率改变，无论瞳孔大小。结果当考虑散瞳的光学效应时，在静态和动态调节下，滴加PHCl之前和之后的响应差异分别为0.51±0.53 D和0.12±0.15，具有统计学意义（p <0.039）。如果不考虑散瞳的光学效应，则在静态和动态调节下，PHCl滴注前后的响应差异分别为？0.20±0.51 D和？0.05±0.14，且无统计学意义（p> 0.313）。 。结论PHCl的散瞳作用会引起眼睛的光学变化，从而减少客观和主观的适应性测量。

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