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首页> 外文期刊>Journal of Optometry >Accuracy of Visante and Zeiss-Humphrey Optical Coherence Tomographers and their cross calibration with optical pachymetry and physical references
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Accuracy of Visante and Zeiss-Humphrey Optical Coherence Tomographers and their cross calibration with optical pachymetry and physical references

机译：Visante和Zeiss-Humphrey光学相干断层扫描仪的准确性以及使用光学测厚法和物理参考的交叉校准

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Purpose: To calibrate the new ZEISS VisanteTM anterior segment optical coherence tomographer (OCT) using references with known physical thickness and refractive index equal to the human cornea and to compare the Visante measures to those from a previous generation OCT (Zeiss-Humphrey OCT II). Methods: Twenty two semi-rigid lenses of specified thicknesses were manufactured using a material with refractive index of 1.376. Central thickness of these lenses was measured using VisanteTM and Zeiss-Humphrey OCT II OCT's (Zeiss, Germany). Two data sets consisting of nominal measures (with a standard pachymeter) of the lenses and one obtained using a digital micrometer was used as references. Regression equations between the new physical and optical (OCT) measures were derived to calibrate the devices. Results: Before calibration, repeated measures ANOVA showed that there were significant differences between mean lens thicknesses from each of the measurement methods (p<0.01), where Visante measurements were significantly different from the other three (OCT II, MG and OP) methods (p<0.001). Visante thickness was significantly higher than the microgauge measures (453+/-37.6 compared to 445.1+/-38.2) and the OCT II was significantly lower (424.5+/-36.1 both, p<0.001). After calibration using the regressions between physical and optical measurements, there were no differences between OCT II and Visante (p<0.05). Conclusions: Using references lenses with refractive index of the cornea (1.376) allows rapid and simple calibration and cross calibration of instruments for measuring the corneal thickness. The Visante and OCT II do not produce measurements that are equal to physical references with refractive index equal to the human cornea.
机译：目的：使用已知物理厚度和折光指数等于人类角膜的参考物来校准新型蔡司VisanteTM前段光学相干断层扫描仪（OCT），并将Visante量度与上一代OCT（Zeiss-Humphrey OCT II）的量度进行比较。方法：使用折射率为1.376的材料制造了22个指定厚度的半刚性镜片。这些镜片的中心厚度是使用VisanteTM和Zeiss-Humphrey OCT II OCT（德国蔡司）测量的。将由镜片的标称量度（使用标准测厚仪）组成的两个数据集和使用数字千分尺获得的一个数据集用作参考。推导了新的物理和光学（OCT）度量之间的回归方程式，以校准设备。结果：校正前，重复测量ANOVA表明，每种测量方法的平均镜片厚度之间存在显着差异（p <0.01），其中Visante测量与其他三种方法（OCT II，MG和OP）显着不同（ p ＜0.001）。 Visante厚度显着高于微分尺（453 +/- 37.6，相比于445.1 +/- 38.2），OCT II显着更低（两者均为424.5 +/- 36.1，p <0.001）。使用物理和光学测量之间的回归进行校准后，OCT II和Visante之间没有差异（p <0.05）。结论：使用具有角膜折射率（1.376）的参考镜片可以快速，简单地校准和交叉校准用于测量角膜厚度的仪器。 Visante和OCT II所产生的测量结果与折光率等于人类角膜的物理参考值不相等。

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