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首页> 外文期刊>Journal of Optometry >Herpes-zoster virus ophthalmicus as presenting sign of HIV disease
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Herpes-zoster virus ophthalmicus as presenting sign of HIV disease

机译：眼科带状疱疹病毒是HIV疾病的征兆

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After a childhood episode of chicken pox, a Varicella-Zoster infection, the viral DNA reside in a dormant state in the dorsal root ganglia. The viruses get reactivated when the individual is immuno-compromised, in adulthood to cause characteristic lesions of Herpes zoster on the skin and the eyes. This case reports a 32 year old female who presented with neuralgia and clinical features of crusting skin ulcers involving the ophthalmic division of the trigeminal nerve, corneal dendritis and anterior uveitis with circumlimbal injection of the right eye. Visual acuity was OD: 6/60 and 0S:6/9. These clinical signs and symptoms were consistent with Herpes Zoster Ophthalmicus (HZO). Further medical laboratory tests showed positive for HIV and patient had a CD4^+ count of 350 cells/@ml of blood with a viral load of 100,000 copies/@ml. Patient was subsequently treated of the Herpes zoster infection with Acyclovir (800mg) prescribed five times daily for 7 days. While, at the HIV/AIDS project facility she was placed on Hyper Active Antiretroviral therapy (HAART): Stavudine (30mg) bid for 2/12, Zidovudine (300mg) bid for 2/12 and Efavirenz (600mg) nocte for 2/12. There was complete resolution of the keratopathy, the visual acuity of OD improved to 6/12 by the 2^n^d month and the patient was without the experience of post herpetic neuralgia. At present (after 3 months) her CD4^+ has increased to 1000 cells/@ml. HIV infection should always be considered in patients younger than 65 years with Herpes zoster ophthalmicus.
机译：在儿童期水痘，带状疱疹感染后，病毒DNA处于休眠状态，位于背根神经节。在成年后免疫功能低下的个体会重新激活病毒，从而在皮肤和眼睛上引起带状疱疹的特征性病变。该病例报告了一名32岁的女性，伴有右眼骨注射，表现出神经痛和涉及三叉神经眼科，角膜树突炎和前葡萄膜炎的结skin性皮肤溃疡的临床特征。视敏度为OD：6/60和0S：6/9。这些临床症状和体征与带状疱疹眼药（HZO）一致。进一步的医学实验室测试表明，HIV阳性，患者的CD4 +计数为350细胞/毫升血液，病毒载量为100,000拷贝/毫升。随后用阿昔洛韦（800mg）每天五次开处方，治疗患者的带状疱疹感染，持续7天。同时，在艾滋病毒/艾滋病项目设施中，她接受了抗逆转录病毒疗法（HAART）的治疗：司他夫定（30mg）竞标2/12，齐多夫定（300mg）竞标2/12和依法韦伦（600mg）诺卡特2/12。 。角膜病变已完全解决，到第2个月，OD的视力提高到6/12，患者没有疱疹后神经痛的经历。目前（3个月后），她的CD4 ^ +已经增加到1000个细胞/ ml。 65岁以下眼带状疱疹患者应始终考虑HIV感染。

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