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首页> 外文期刊>Journal of Ophthalmology >Size of the Optic Nerve Head and Its Relationship with the Thickness of the Macular Ganglion Cell Complex and Peripapillary Retinal Nerve Fiber Layer in Patients with Primary Open Angle Glaucoma
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Size of the Optic Nerve Head and Its Relationship with the Thickness of the Macular Ganglion Cell Complex and Peripapillary Retinal Nerve Fiber Layer in Patients with Primary Open Angle Glaucoma

机译：原发性开角型青光眼患者视神经头的大小及其与黄斑神经节细胞复合物和乳头周围视网膜神经纤维层厚度的关系

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Purpose. To evaluate the relationships among the optic nerve head (ONH) area, macular ganglion cell complex (mGCC) thickness, circumpapillary retinal nerve fiber layer (cpRNFL) thickness, and visual field defects in patients with primary open angle glaucoma (POAG).Methods. This retrospective study included 90 eyes of 90 patients with POAG. The ONH area, rim area, mGCC thickness, and cpRNFL thickness were measured using optical coherence tomography. Mean deviation (MD) was measured using standard automated perimetry. The relationships among clinical factors including age, refraction, the ONH area, the rim area, the mGCC thickness, the cpRNFL thickness, and MD were evaluated using correlation coefficients and multiple regression analyses.Results. The significant correlation of the ONH area with refraction (r=0.362,P<0.001), the mGCC thickness (r=0.225,P=0.033), and the cpRNFL thickness (r=0.253,P=0.016) was found. Multiple regression analysis showed that the ONH area, rim area, and MD were selected as significant contributing factors to explain the mGCC thickness and cpRNFL thickness. No factor was selected to explain MD.Conclusions. The ONH area, in other words, the disc size itself may affect the mGCC thickness and cpRNFL thickness in POAG patients.
机译：目的。目的评估原发性开角型青光眼（POAG）患者的视神经头（ONH）面积，黄斑神经节细胞复合物（mGCC）厚度，乳头状视网膜神经纤维层（cpRNFL）厚度与视野缺损之间的关系。这项回顾性研究包括90例POAG患者的90眼。使用光学相干断层扫描技术测量ONH面积，边缘面积，mGCC厚度和cpRNFL厚度。使用标准自动视野检查法测量平均偏差（MD）。使用相关系数和多元回归分析评估了年龄，屈光度，ONH面积，边缘面积，mGCC厚度，cpRNFL厚度和MD等临床因素之间的关系。发现ONH面积与折射（r ＝ 0.362，P ＜0.001），mGCC厚度（r ＝ 0.225，P ＝ 0.033）和cpRNFL厚度（r ＝ 0.253，P ＝ 0.016）之间显着相关。多元回归分析表明，选择ONH面积，边缘面积和MD作为解释mGCC厚度和cpRNFL厚度的重要因素。没有选择任何因素来解释MD。结论。 ONH区域，换句话说，光盘大小本身可能会影响POAG患者的mGCC厚度和cpRNFL厚度。

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