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首页> 外文期刊>Journal of Molecular Psychiatry >Circadian and behavioural responses to shift work-like schedules of light/dark in the mouse
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Circadian and behavioural responses to shift work-like schedules of light/dark in the mouse

机译：昼夜节律和行为反应，以改变鼠标中类似工作的明/暗时间表

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BackgroundDisruption of circadian rhythms is associated with several deleterious health consequences and cognitive impairment. It is estimated that as many as one in five workers are exposed to this risk factor due to experiencing some degree of chronodisruption by way of recurring patterns of shift work. It is not presently clear therefore how efficiently the mammalian circadian system entrains to alternative light/dark cycles such as those found in shift work schedules. MethodsThe present study examines male CD-1 mice exposed to three different paradigms of rapidly rotating shift work-like light/dark manipulations compared to control animals maintained on a standard 12:12 h light/dark cycle. ResultsAnalysis of circadian patterns of behaviour under such conditions reveals that for fast rotating schedules of light/dark there is minimal circadian entrainment. Further, when placed in constant conditions after a period under the “shift work” lighting conditions there were changes to circadian period associated with the shift work schedules. In contrast to previous studies the shift work-like conditions did not produce changes in animal body-weight. Behavioural testing suggests possible anxiogenic and hyperactive outcomes dependent on rotation speed as animals displayed open field thigmotaxis and hyperlocomotion. ConclusionThese results indicate that exposure to alternating patterns of light and dark as experienced by millions of shift workers may produce long-lasting changes in both mammalian circadian and neurobehavioural systems.
机译：背景昼夜节律的破坏与几种有害的健康后果和认知障碍有关。据估计，由于轮班制的反复出现，由于某种程度的计时颠倒，多达五分之一的工人暴露于这一危险因素。因此，目前尚不清楚哺乳动物昼夜节律系统如何有效地带动交替的明/暗周期，例如在轮班工作时间表中发现的周期。方法：本研究检查了与在标准12:12 h亮/暗周期下维持正常状态的对照动物相比，暴露于三种不同范式的快速旋转轮班工作式明/暗操纵的雄性CD-1小鼠。结果在这种情况下对昼夜节律行为的分析表明，对于明/暗快速旋转的日程，昼夜节律的夹带最少。此外，当在“轮班”照明条件下放置一段时间后处于恒定状态时，与轮班工作时间表相关的昼夜节律发生变化。与以前的研究相反，类似轮班工作的条件不会产生动物体重的变化。行为测试表明，取决于动物表现出的开阔地垂直运动和运动过度，可能取决于旋转速度而引起焦虑和过度活跃。结论这些结果表明，数百万轮班工人经历的明暗交替模式可能会在哺乳动物的昼夜节律和神经行为系统中产生长期的变化。

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