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首页> 外文期刊>Journal of Oral Microbiology >The effect of metronidazole plus amoxicillin or metronidazole plus penicillin V on a periodontal biofilm model. An in vitro study.
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The effect of metronidazole plus amoxicillin or metronidazole plus penicillin V on a periodontal biofilm model. An in vitro study.

机译：甲硝唑加阿莫西林或甲硝唑加青霉素V对牙周生物膜模型的影响。体外研究。

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Background: Antibiotic resistance has become life-threatening. A combination of metronidazole and amoxicillin is commonly used as adjunct to periodontal therapy. The aim of this study was to utilize an in vitro biofilm model to test the effect of replacing the broad-spectrum amoxicillin with penicillin V in the combination with metronidazole.Methods: An in vitro biofilm model, consisting of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Fusobacterium nucleatum was developed. Biofilms were exposed to chlorhexidine digluconate (CHX) 0.2%, as positive control, and either to metronidazole/amoxicillin or metronidazole/penicillin V in two different concentrations. Statistical significance was achieved if p 0.05 with paired t-test.Results: There was no growth of any bacterial species after 2h exposure to 0.2% CHX. Together, the two combinations of antibiotics were effective against F. nucleatum and P. gingivalis, but less effective against A. actinomycetemcomitans. No significant d...
机译：背景：抗生素耐药性已威胁生命。甲硝唑和阿莫西林的组合通常用作牙周治疗的辅助手段。这项研究的目的是利用体外生物膜模型来测试用青霉素V与甲硝唑联用替代广谱阿莫西林的效果。核发达。将生物膜暴露于0.2％的氯己定二葡萄糖酸酯（CHX）（作为阳性对照），并暴露于两种不同浓度的甲硝唑/阿莫西林或甲硝唑/青霉素V。如果配对t检验的p <0.05，则具有统计学意义。结果：暴露于0.2％CHX 2h后，任何细菌种类均无生长。在一起，两种抗生素的组合对核镰刀菌和牙龈卟啉单胞菌有效，但对放线放线杆菌不那么有效。没有明显的问题

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