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首页> 外文期刊>Journal of Oral Microbiology >The cagE gene sequence as a diagnostic marker to identify JP2 and non-JP2 highly leukotoxic Aggregatibacter actinomycetemcomitans serotype b strains
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The cagE gene sequence as a diagnostic marker to identify JP2 and non-JP2 highly leukotoxic Aggregatibacter actinomycetemcomitans serotype b strains

机译：cagE基因序列作为鉴定JP2和非JP2高白毒性聚合酶放线杆菌血清型b菌株的诊断标记

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Aggregatibacter actinomycetemcomitans is associated with aggressive forms of periodontitis, and with systemic infections such as endocarditis. The cagE gene encodes a ≈39-kDa putative exotoxin expressed by A. actinomycetemcomitans. The prevalence of cagE, and its significance in periodontal disease, has not yet been thoroughly evaluated. In the present study, the role of the cagE gene as a diagnostic marker has been investigated.We have used PCR, and whole genome sequencing data to determine the prevalence of cagE in A. actinomycetemcomitans based on analysis of (i) 249 isolates, collected and cultivated in a Ghanaian longitudinal cohort study, (ii) a serotype b collection of 19 strains, and (iii) the 36 A. actinomycetemcomitans genomes available in the NCBI database.Whereas cagE was absent in the other serotypes, this gene sequence was linked to a virulent and highly leukotoxic group of serotype b strains, including both JP2 and non-JP2 genotypes.We therefore propose that cagE has a potential to ...
机译：放线杆菌聚集体与侵袭性牙周炎有关，并与全身感染如心内膜炎有关。 cagE基因编码由放线放线杆菌表达的大约39-kDa的外毒素。 cagE的流行及其在牙周疾病中的意义尚未得到全面评估。在本研究中，已研究了cagE基因作为诊断标志物的作用。我们已使用PCR和全基因组测序数据，基于对（i）249株分离物的分析，确定了cagE在拟南芥放线杆菌中的患病率。并在加纳的纵向队列研究中进行了培养，（ii）收集了19个菌株的b型血清型，和（iii）NCBI数据库中提供的36个A.放线菌基因组。到强毒和高度白细胞毒性的血清型b株，包括JP2和非JP2基因型，因此我们认为cagE有潜力...

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