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首页> 外文期刊>Journal of Oral Microbiology >The microbiome of oral leukoplakia shows enrichment in Fusobacteria and Rothia species
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The microbiome of oral leukoplakia shows enrichment in Fusobacteria and Rothia species

机译：口腔白斑的微生物组显示富集细菌和Rothia物种丰富

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The current study was carried out to determine if changes in the oral microbiome were associated with oral leukoplakia. Swabs of oral leukoplakias were taken from 36 patients. Contralateral normal tissue was also swabbed. Swabs from 35 control patients without symptoms of leukoplakia were also taken. DNA was extracted and the V1V2 region of the 16s rRNA gene was sequenced using the Illumina MiSeq and analysed using the Mothur software package.The structure of oral mucosal communities was most affected by smoking and the location of the site (AMOVA p 0.01). Analysis of the constituents of these communities using LEfSe showed that Fusobacterium sp. and Leptotrichia sp. were enriched on leukoplakia sites. Patients with leukoplakia also showed enrichment for Rothia mucilaginosa and Campylobacter sp. Quantitative RT-PCR also showed that leukoplakias from lingual sites were more likely to be colonised by Candida sp. Analysis of these enrichments identified specific co-localisation patterns (Pearson co...
机译：目前的研究是为了确定口腔微生物组的变化是否与口腔白斑相关。口腔白斑拭子取自36例患者。对侧正常组织也被擦拭。还采集了35名无白斑症状的对照患者的拭子。提取DNA并使用Illumina MiSeq对16s rRNA基因的V1V2区域进行测序，并使用Mothur软件包进行分析。口腔黏膜群落的结构受吸烟和位点位置的影响最大（AMOVA p <0.01）。使用LEfSe对这些群落的组成进行分析，结果显示Fusobacterium sp.。和Leptotrichia sp。在白斑部位富集。白斑患者还显示出Rothia mucilaginosa和弯曲杆菌sp的富集。定量RT-PCR还显示来自舌部位的白斑更可能被假丝酵母菌定殖。对这些富集的分析确定了特定的共定位模式（Pearson co ...

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