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首页> 外文期刊>Journal of Oral Microbiology >Role of Porphyromonas gingivalis’s peptidylarginine deiminase in multispecies biofilm formation and bacterial adherence to host cells
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Role of Porphyromonas gingivalis’s peptidylarginine deiminase in multispecies biofilm formation and bacterial adherence to host cells

机译：牙龈卟啉单胞菌肽丝氨酸精氨酸脱亚氨酶在多种生物膜形成和细菌对宿主细胞粘附中的作用

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Porphyromonas gingivalis’s peptidylarginine deiminase (PPAD) is one of the most unique virulence factors in the pathogenesis of periodontitis, as well as one of the possible links between this chronic inflammatory disease and other disorders, like rheumatoid arthritis. However, it is yet unclear how it is involved in the infection of epithelial cells, therefore the aim of this study was to examine whether PPAD enzyme has an effect on the formation of biofilm by P. gingivalis in consortium with four other bacteria species, and the bacterial adhesion and invasion of gingival keratinocytes and their subsequent response. Using PPAD-deficient strains, we have demonstrated that its activity has no effect on P. gingivalis’s ability to form a biofilm, nor does it change the species composition in such a formation. Moreover, flow cytometry analysis of the adhesion and invasion of keratinocytes by those bacteria did not reveal any difference depending on PPAD activity, which was further supported by the ana...
机译：牙龈卟啉单胞菌肽丝氨酸精氨酸脱亚氨酶（PPAD）是牙周炎发病机理中最独特的毒力因子之一，也是这种慢性炎症性疾病与类风湿关节炎等其他疾病之间可能的联系之一。但是，尚不清楚它如何参与上皮细胞的感染，因此，本研究的目的是检验PPAD酶是否对与其他四种细菌组成的联合体中牙龈卟啉单胞菌的生物膜形成具有影响，并且牙龈角质形成细胞的细菌粘附和侵袭及其后续反应。使用PPAD缺陷菌株，我们已经证明其活性不会影响牙龈卟啉单胞菌形成生物膜的能力，也不会改变这种形成的物种组成。此外，流式细胞仪分析那些细菌对角质形成细胞的粘附和侵袭没有显示出取决于PPAD活性的任何差异，这一点进一步得到了分析的支持。

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