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首页> 外文期刊>Journal of Oral Microbiology >Probiotic intervention improves gingival status and influences the salivary levels of Matrix Metalloproteinase (MMP)-9 and Tissue Inhibitor of metalloproteinases (TIMP)-1 in healthy adults
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Probiotic intervention improves gingival status and influences the salivary levels of Matrix Metalloproteinase (MMP)-9 and Tissue Inhibitor of metalloproteinases (TIMP)-1 in healthy adults

机译：益生菌干预可改善健康成年人的牙龈状况，并影响唾液中基质金属蛋白酶（MMP）-9和组织金属蛋白酶抑制剂（TIMP）-1的水平

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The effect of orally administered Bifidobacterium animalis subsp. lactis BB-12 and Lactobacillus rhamnosus GG on the amount of plaque, gingival inflammation, oral microbiota and salivary mutans streptococci, as well as on levels of Matrix Metalloproteinases (MMP)-8, MMP-9, and of Tissue Inhibitor of Metalloproteinases (TIMP)-1 in healthy adults was studied.The study was a randomized controlled trial with a four-week study period. The saliva samples were collected and clinical parameters measured at the baseline and at the end of the study.In the probiotic group, the plaque and gingival indices reduced, salivary MMP-9 levels increased (p=0.007) and TIMP-1 levels decreased (p=0.003) significantly during the intervention. These changes were not observed in control group. In addition, the probiotic intervention had no effect on salivary microbiota.To conclude, improved gingival status with increased MMP-9 and decreased TIMP-1 levels in saliva may indicate that probiotics have immunomodulatory effects ...
机译：口服动物双歧杆菌亚种的作用。乳酸菌BB-12和鼠李糖乳杆菌GG在斑块，牙龈发炎，口腔微生物群和唾液变形链球菌的含量以及基质金属蛋白酶（MMP）-8，MMP-9和金属蛋白酶组织抑制剂（TIMP）的含量上）-1在健康成年人中进行了研究。该研究是一项为期四周的随机对照试验。在基线和研究结束时收集唾液样本并测量临床参数。在益生菌组中，牙菌斑和牙龈指数降低，唾液MMP-9水平升高（p = 0.007），TIMP-1水平降低（ p = 0.003）。在对照组中未观察到这些变化。此外，益生菌干预对唾液微生物没有影响。总而言之，随着唾液中MMP-9的增加和TIMP-1水平的降低，牙龈状态改善可能表明益生菌具有免疫调节作用。

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