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New approaches to combat Porphyromonas gingivalis biofilms

机译:对抗牙龈卟啉单胞菌生物膜的新方法

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In nature, bacteria predominantly reside in structured, surface-attached communities embedded in a self-produced, extracellular matrix. These so-called biofilms play an important role in the development and pathogenesis of many infections, as they are difficult to eradicate due to their resistance to antimicrobials and host defense mechanisms. This review focusses on the biofilm-forming periodontal bacterium Porphyromonas gingivalis. Current knowledge on the virulence mechanisms underlying P. gingivalis biofilm formation is presented. In addition, oral infectious diseases in which P. gingivalis plays a key role are described, and an overview of conventional and new therapies for combating P. gingivalis biofilms is given. More insight into this intriguing pathogen might direct the development of better strategies to combat oral infections.
机译:在自然界中,细菌主要生活在嵌入自生的细胞外基质中的结构化,表面附着的群落中。这些所谓的生物膜在许多感染的发生和发病机理中起着重要作用,因为由于它们对抗菌剂和宿主防御机制的抵抗力而难以根除。这篇综述集中在形成生物膜的牙周细菌牙龈卟啉单胞菌。介绍了有关牙龈卟啉单胞菌生物膜形成的毒力机制的最新知识。另外,描述了其中牙龈卟啉单胞菌起关键作用的口腔感染性疾病,并且概述了对抗牙龈卟啉单胞菌生物膜的常规和新疗法的概述。对这种有趣的病原体的更多了解可能会指导开发更好的策略来对抗口腔感染。

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