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首页> 外文期刊>Journal of Oral Microbiology >Porphyromonas gingivalis is the most abundant species detected in coronary and femoral arteries
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Porphyromonas gingivalis is the most abundant species detected in coronary and femoral arteries

机译：牙龈卟啉单胞菌是在冠状动脉和股动脉中检测到的最丰富的物种

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An association between oral bacteria and atherosclerosis has been postulated. A limited number of studies have used 16S RNA gene sequencing-based metagenomics approaches to identify bacteria at the species level from atherosclerotic plaques in arterial walls. The objective of this study was to establish detailed oral microbiome profiles, at both genus and species level, of clinically healthy coronary and femoral artery tissues from patients with atherosclerosis. Tissue specimens were taken from clinically non-atherosclerotic areas of coronary or femoral arteries used for attachment of bypass grafts in 42 patients with atherosclerotic cardiovascular disease. Bacterial DNA was sequenced using the MiSeq platform, and sequence reads were screened in silico for nearly 600 oral species using the HOMINGS ProbeSeq species identification program. The number of sequence reads matched to species or genera were used for statistical analyses. A total of 230 and 118 species were detected in coronary and femoral...
机译：口腔细菌和动脉粥样硬化之间的关联已被假定。有限的研究已经使用基于16S RNA基因测序的宏基因组学方法从动脉壁的动脉粥样硬化斑块中识别细菌。这项研究的目的是建立从动脉粥样硬化患者的临床健康冠状动脉和股动脉组织的详细的口腔微生物组概况，包括属和种水平。组织标本取自42例患有动脉粥样硬化性心血管疾病的患者的冠状动脉或股动脉的临床非动脉粥样硬化区域，用于搭桥。使用MiSeq平台对细菌DNA进行测序，并使用HOMINGS ProbeSeq物种鉴定程序在计算机上筛选近600种口腔物种的序列读数。与物种或属相匹配的序列读数的数目用于统计分析。在冠状动脉和股骨中共检测到230和118种。

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