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首页> 外文期刊>Journal of Oral Microbiology >The role of Aggregatibacter actinomycetemcomitans and its leukotoxin in periodontitis
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The role of Aggregatibacter actinomycetemcomitans and its leukotoxin in periodontitis

机译：放线杆菌聚合酶及其白细胞毒素在牙周炎中的作用

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Aggregatibacter actinomycetemcomitans is a Gram-negative periodontitis-associated bacterium that expresses a toxin that selectively affects leukocytes. Leukotoxin is encoded by an operon belonging to the core genome of this bacterial species. Variations in the expression of the leukotoxin have been reported, and a specific clonal type (JP2) of this bacterium with enhanced leukotoxin expression has been identified. Experimental studies have shown that leukotoxin, besides to kill leukocytes, also activates a substantial pro-inflammatory response in these cells. Characterization of clinical isolates from individuals with different geographic origin, age and periodontal status linked carriership of highly leukotoxic A. actinomycetemcomitans to disease. These highly virulent bacteria are of serotype b and have several common phenotypic and genetic features. Based on a great genetic diversity, A. actinomycetemcomitans can be distributed into a high number of different genotypes with various virulence ca...
机译：放线杆菌聚合酶是一种革兰氏阴性牙周炎相关细菌，它表达一种选择性影响白细胞的毒素。白细胞毒素由属于该细菌物种核心基因组的操纵子编码。已经报道了白细胞毒素表达的变化，并且已经鉴定出具有增强的白细胞毒素表达的该细菌的特定克隆类型（JP2）。实验研究表明，白细胞毒素除了杀死白细胞外，还可以激活这些细胞中的实质性促炎反应。来自具有不同地理起源，年龄和牙周状态的个体的临床分离株的特征将高度白毒性的放线放线杆菌的携带者与疾病联系起来。这些高毒力细菌为血清型b，具有几种常见的表型和遗传特征。基于巨大的遗传多样性，放线放线杆菌可被分配到具有不同毒力的大量不同基因型中。

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