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首页> 外文期刊>Journal of orthopaedics and traumatology: official journal of the Italian Society of Orthopaedics and Traumatology >The effect of tranexamic acid on artificial joint materials: a biomechanical study (the bioTRANX study)
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The effect of tranexamic acid on artificial joint materials: a biomechanical study (the bioTRANX study)

机译：氨甲环酸对人工关节材料的影响：一项生物力学研究（bioTRANX研究）

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Tranexamic acid (TXA) has been successfully used to reduce bleeding in joint replacement. Recently local TXA has been advocated to reduce blood loss in total knee or hip replacement; however, this raised concerns about potential adverse effects of TXA upon the artificial joint replacement. In this biomechanical study we compared the effects of TXA and saline upon the following biomechanical properties of artificial joint materials—(1) tensile properties (ultimate strength, stiffness and Young’s modulus), (2) the wear rate using a multi-directional pin-on-plate machine, and (3) the surface topography of pins and plates before and after wear rate testing. There were no significant differences in tensile strength, wear rates or surface topography of either ultra-high-molecular-weight polyethylene pins or cobalt chromium molybdenum metal plates between specimens soaked in TXA and specimens soaked in saline. Biomechanical testing shows that there are no biomechanical adverse affects on the properties of common artificial joint materials from using topical TXA. V
机译：氨甲环酸（TXA）已成功用于减少关节置换术中的出血。最近，人们提倡局部TXA减少全膝或髋关节置换术中的失血量。然而，这引起了对TXA对人工关节置换术的潜在不利影响的担忧。在这项生物力学研究中，我们比较了TXA和盐水对以下人造关节材料生物力学性能的影响：（1）拉伸性能（最终强度，刚度和杨氏模量），（2）使用多向销钉的磨损率（3）磨损率测试前后销和板的表面形貌。浸泡在TXA中的样品和浸泡在盐水中的样品之间，超高分子量聚乙烯销或钴铬钼金属板的拉伸强度，磨损率或表面形貌无显着差异。生物力学测试表明，使用局部TXA对普通人工关节材料的性能没有生物力学不利影响。 V

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