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首页> 外文期刊>Journal of orthopaedics and traumatology: official journal of the Italian Society of Orthopaedics and Traumatology >Hydroxyapatite and demineralized calf fetal growth plate effects on bone healing in rabbit model
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Hydroxyapatite and demineralized calf fetal growth plate effects on bone healing in rabbit model

机译：羟基磷灰石和去矿质小牛胎儿生长板对兔模型骨愈合的影响

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Synthetic hydroxyapatite (HA), beta-tricalcium phosphate (β-TCP) and their composite are promising biomaterials, specifically in the orthopedic and dental fields, as their chemical composition is similar to that of bone. Due to the need for safer bone graft applications, these bone graft substitutes are gradually gaining increased acceptability. To stimulate the process of bone healing, several methods have been used previously, including ultrasound, electrical stimulation, exposure to electromagnetic fields, bone grafts, interporous hydroxyapatite (as a bone graft substitute) and bone growth factors. The following study was designed to evaluate the effects of the concurrent usage of hydroxyapatite with demineralized calf fetal growth plate (DCFGP) on the bone healing process. Fifteen female New Zealand white rabbits were used in this study. A mid-radius bone defect was created and in the first group (n = 5) was filled with hydroxyapatite, in the second group (n = 5) with hydroxyapatite and DCFGP, and finally in the third group (n = 5) with DCFGP alone. Radiological and histopathological evaluations were performed blindly and the results scored and analyzed statistically. There was a significant difference for bone formation and remodeling at the 8th post-operative week radiographic assessment (P 0.05), when the hydroxyapatite–DCFGP group was superior to other groups. On the contrary, macroscopical and histopathological evaluation did not revealed significant differences between the three groups Given the contrasting results of the radiographic assessment and the macro-/microscopic analysis of the healing response, further studies are needed before considering DCFGP-HA as a feasible alternative to HA alone, especially considering the potential hazards and costs of animal-derived biomaterials. Not applicable.
机译：合成羟基磷灰石（HA），β-磷酸三钙（β-TCP）及其复合材料是有前途的生物材料，特别是在整形外科和牙科领域，因为它们的化学组成与骨骼相似。由于需要更安全的骨移植应用，这些骨移植替代品逐渐获得了越来越多的认可。为了刺激骨愈合过程，以前已经使用了几种方法，包括超声，电刺激，暴露于电磁场，骨移植物，多孔羟基磷灰石（作为骨移植物的替代物）和骨生长因子。以下研究旨在评估羟基磷灰石与软化小牛胎儿生长板（DCFGP）的同时使用对骨愈合过程的影响。在该研究中使用了15只雌性新西兰白兔。产生了-骨中部骨缺损，第一组（n = 5）充满了羟基磷灰石，第二组（n = 5）充满了羟基磷灰石和DCFGP，最后在第三组（n = 5）中充满了DCFGP单独。盲法进行放射学和组织病理学评估，并对结果进行评分和统计分析。当羟基磷灰石-DCFGP组优于其他组时，在术后第8周的放射学评估中，骨形成和重塑存在显着差异（P <0.05）。相反，宏观和组织病理学评估未显示三组之间的显着差异。鉴于放射线照相评估和愈合反应的宏观/微观分析结果相反，在将DCFGP-HA视为可行替代方案之前，需要进一步研究仅限于HA，尤其要考虑到动物衍生生物材料的潜在危害和成本。不适用。

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