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首页> 外文期刊>Journal of orthopaedics and traumatology: official journal of the Italian Society of Orthopaedics and Traumatology >Nitric oxide-associated chondrocyte apoptosis in trauma patients after high-energy lower extremity intra-articular fractures
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Nitric oxide-associated chondrocyte apoptosis in trauma patients after high-energy lower extremity intra-articular fractures

机译：高能下肢关节内骨折后创伤患者中一氧化氮相关的软骨细胞凋亡

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class="Heading">Background id="Par1" class="Para">The primary goal of this study was to identify nitric oxide (NO)-induced apoptosis in traumatized chondrocytes in intra-articular lower extremity fractures and the secondary goal was to identify the timeline of NO-induced apoptosis after injury. class="Heading">Materials and methods id="Par2" class="Para">This is a prospective collection of samples of human cartilage harvested at the time of surgery to measure apoptotic cell death and the presence of NO by immunohistochemistry. Three patients met the criteria for control subjects and eight patients sustained high-energy intra-articular fractures and were included in the study. Subjects who sustained intra-articular acetabular, tibial, calcaneal and talus fracture had articular cartilage harvested at the time of surgical intervention. All 8 patients underwent open reduction and internal fixation of the displaced intra-articular fractures. The main outcome measures were rate of apoptosis, degree of NO-induced apoptosis in chondrocytes, and the timeline of NO-induced apoptosis after high-energy trauma. class="Heading">Results id="Par3" class="Para">The percentage of apoptotic chondrocytes was higher in impacted samples than in normal cartilage (56 vs 4?%), confirming the presence of apoptosis after intra-articular fracture. The percentage of cells with NO was greater in apoptotic cells than in normal cells (59 vs 20?%), implicating NO-induction of apoptosis. The correlation between chondrocyte apoptosis and increasing time from injury was found to be ?0.615, indicating a decreasing rate of apoptosis post injury. class="Heading">Conclusions id="Par4" class="Para">The data showed the involvement of NO-induced apoptosis of chondrocytes after high-energy trauma, which decreased with time from injury.
机译：class =“ Heading”>背景 id =“ Par1” class =“ Para”>这项研究的主要目的是确定一氧化氮（NO）诱导的关节内软骨细胞的凋亡下肢骨折，次要目标是确定损伤后NO诱导凋亡的时间表。 class =“ Heading”>材料和方法 id =“ Par2” class =“ Para ＞这是在手术时收集的预期收集的人类软骨样品，用于通过免疫组织化学测量凋亡细胞死亡和NO的存在。三名患者符合对照组的标准，八名患者发生了高能量关节内骨折，被纳入研究。持续发生髋臼内，胫骨，跟骨和距骨骨折的受试者在进行外科手术时收获了关节软骨。全部8例患者均行切开复位复位移位的关节内骨折内固定。主要预后指标为细胞凋亡率，软骨细胞一氧化氮诱导的凋亡程度以及高能创伤后一氧化氮诱导凋亡的时间表。 class =“ Heading”>结果 <受影响的样品中凋亡软骨细胞的百分比高于正常软骨（56 vs 4％），证实了关节内骨折后细胞凋亡的存在。凋亡细胞中具有NO的细胞百分比比正常细胞中更大（59比20％），这暗示NO诱导了细胞凋亡。软骨细胞凋亡与损伤时间延长之间的相关性约为0.615，表明损伤后细胞凋亡率降低。 class =“ Heading”>结论 id =“ Par4” class =“ Para”>数据显示，高能创伤后，NO参与了软骨细胞凋亡，并随着受伤时间的延长而减少。

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