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首页> 外文期刊>Journal of Oral Microbiology >Multilevel analysis of bacterial counts from chronic periodontitis after root planing/scaling, surgery, and systemic and local antibiotics: 2-year results
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Multilevel analysis of bacterial counts from chronic periodontitis after root planing/scaling, surgery, and systemic and local antibiotics: 2-year results

机译：根治/刮治，手术以及全身和局部抗生素治疗后慢性牙周炎细菌计数的多级分析：2年结果

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Aim:Tofollowchanges(over2years)insubgingivalbacterialcountsoffivemicrobialcomplexesincludinghealth-relatedActinomycesspp.indeeperpockets(≥5mm)afterperiodontaltreatments.Methods:Eightdifferenttreatmentswerestudied:(1)scalingrootplaning(SRP);(2)periodontalsurgery(SURG)systemicamoxicillin(AMOX)systemicmetronidazole(MET);(3)SURGlocallydeliveredtetracycline(TET);(4)SURG;(5)AMOXMETTET;(6)AMOXMET;(7)TET;and(8)SURGAMOXMETTET.AntibioticsweregivenimmediatelyfollowingSRP.Subgingivalplaquewascollectedmesiobuccallyfromeachtooth,exceptthirdmolars,from176subjects,completingthestudy,atbaseline,3,6,12,18,and24monthspost-treatmentandanalysedfor40differentbacteriausingcheckerboardhybridization.Anegativebinomial(NB)generalizedestimatingequation(NBGEE)modelwasusedtoanalyzecountdataandalogisticGEEwasusedforproportions.Results:Weobservedshort-termbeneficialchangesinthecompositionoftheredcomplexofupto3monthsbytreatingsubjectswithAMOXMETTET.Similarshort-termimprovementswiththesametreatmentwereobservedforTannerellaforsythiaandTreponemadenticolaoftheredcomplex.SURGhadalsoshorttermbeneficialeffectonPorphyromonasgingivalis.NoperiodontaltreatmentsappliedtoseverelyaffectedsitespromotedthegrowthofActinomyces.Smokingelevatedcountsofboththeredandorangecomplexwhilebleedingonprobing(BOP)andgingivalrednesswerealsopredictorsofmoreredcomplexcounts.Comparativelysimilarfindingswereobtainedbyanalyzingcountsandbyanalyzingproportions.Conclusions:Althoughshort-termreductionsinthecountsoftheredcomplexwereobservedinsitesthatweretreatedwithAMOXMETTET,long-termsignificanteffectswerenotobservedwithanyoftheeighttreatments.Poororalhygieneinpatientswithseverechronicperiodontitisdiminishedthebeneficialeffectsoftreatment.Keywords:microbiota;chronicperiodontitis;periodontaltherapy;antibiotics;multilevelanalysis;NBGEE;fractionalresponsemethods(Published:9July2013)Citation:JournalofOralMicrobiology2013,5:20939-http://dx.doi.org/10.3402/jom.v5i0.20939Accessthesupplementarymaterialtothisarticle–seeSupplementaryfilesunderArticleToolsonline.*TheChiefEditorIngarOlsen,hasnothadanypartinthereviewanddecisionprocessforthispaper.
机译：目的：牙龈下细菌对付微生物复合物的Tofol变化（超过2年），包括牙周治疗后与健康有关的放线菌（≥5mm），深度相关的放疗袋（方法）：方法：八种不同的治疗方法：（1）结垢根刨平（SRP）;环唑烷二甲基（系统）环己酮TET）;（4）SURG;（5）AMOXMETTET;（6）AMOXMET;（7）TET;和（8）SURGAMOXMETTET.SRP之后立即对抗生素进行了牙龈下牙菌斑的采集，除了每三个月，第三个月，第12个，第12个，第3个，第12个，第3个，第6个，第3个，第6个，第一个，第6个，第一个，第6个，第一个，第三个，第三个，第三个，第三个，第三个，第三个，第三个通过使用棋盘杂交对40种不同细菌进行治疗和分析ellaforsythiaandTreponemadenticolaoftheredcomplex.SURGhadalsoshorttermbeneficialeffectonPorphyromonasgingivalis.NoperiodontaltreatmentsappliedtoseverelyaffectedsitespromotedthegrowthofActinomyces.Smokingelevatedcountsofboththeredandorangecomplexwhilebleedingonprobing（BOP）andgingivalrednesswerealsopredictorsofmoreredcomplexcounts.Comparativelysimilarfindingswereobtainedbyanalyzingcountsandbyanalyzingproportions.Conclusions：Althoughshort-termreductionsinthecountsoftheredcomplexwereobservedinsitesthatweretreatedwithAMOXMETTET，长termsignificanteffectswerenotobservedwithanyoftheeighttreatments.Poororalhygieneinpatientswithseverechronicperiodontitisdiminishedthebeneficialeffectsoftreatment.Keywords：微生物群; chronicperiodontitis; periodontaltherapy;抗生素; multilevelanalysis; NBGEE; fractionalresponsemethods（发布时间：9July2013）引文：JournalofOralMicrobiology2013， 5：20939-http：//dx.doi.org/10.3402/jom.v5i0.20939访问本文的补充材料–请参见Arti下的补充文件cleToolsonline。* IngarOlsen主编，这里没有本文的视野和决策过程。

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